Document Detail

Gamma-radiation-induced apoptosis in human colorectal adenoma and carcinoma cell lines can occur in the absence of wild type p53.
MedLine Citation:
PMID:  7784088     Owner:  NLM     Status:  MEDLINE    
The tumour suppressor gene p53 codes for a transcription factor which is thought to play a critical role in the induction of G1 cell cycle arrest and programmed cell death (apoptosis) following DNA damage by ionizing radiation. The aim of this investigation was to determine whether a p53 independent radiation-induced apoptosis pathway exists in human colon epithelial cell lines. This report describes the induction, by gamma-radiation, of apoptosis in the colorectal adenoma cell line S/RG/C2, and in the colorectal carcinoma cell line PC/JW, both of which lack wild type p53. In addition, flow cytometry revealed that both cell lines failed to arrest in G1 after radiation. Thus, although loss of wild type p53 may abrogate G1 arrest, radiation-induced apoptosis can still occur in human colonic tumour cell lines through a p53 independent mechanism.
T S Bracey; J C Miller; A Preece; C Paraskeva
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oncogene     Volume:  10     ISSN:  0950-9232     ISO Abbreviation:  Oncogene     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-07-18     Completed Date:  1995-07-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8711562     Medline TA:  Oncogene     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2391-6     Citation Subset:  IM    
Dept. of Pathology and Microbiology, School of Medical Sciences, University of Bristol, UK.
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MeSH Terms
Adenoma / genetics,  pathology*
Apoptosis* / genetics
Carcinoma / genetics,  pathology*
Colorectal Neoplasms / genetics,  pathology*
DNA Damage
DNA, Neoplasm / radiation effects*
Gamma Rays*
Genes, p53*
Tumor Cells, Cultured
Reg. No./Substance:
0/DNA, Neoplasm

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