Document Detail

Gamma-linolenic acid prevents conjugated linoleic acid-induced fatty liver in mice.
MedLine Citation:
PMID:  15043857     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The present study was done to clarify the mechanism by which conjugated linoleic acid (CLA) induces fatty liver in mice and to attenuate this symptom by adding other dietary fatty acids. METHODS: Mice were given CLA short (12 h) or long (4 wk) term or given CLA with linoleic acid (LA) or gamma-linolenic acid (GLA) in the long term (4 wk). Total lipids, triacylglycerol, and prostaglandin E(2) (PGE(2)) levels in the liver were determined. RESULTS: A single administration of CLA significantly increased PGE(2) levels in the liver 12 h after administration. However, long-term administration of CLA significantly decreased the liver PGE(2) level and induced fatty liver. GLA increased PGE(2) levels, and coadministration with GLA, but not with LA, prevented the CLA-induced fatty liver. CONCLUSIONS: These data suggest that CLA initially stimulates PGE(2) production followed by depletion of PGE(2) sources in the liver. The fatty liver associated with PGE(2) reduction by CLA ingestion can be attenuated by GLA in mice.
Tomonori Nakanishi; Daichi Oikawa; Tomoyuki Koutoku; Hachidai Hirakawa; Yasuhiro Kido; Tetsuya Tachibana; Mitsuhiro Furuse
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  20     ISSN:  0899-9007     ISO Abbreviation:  Nutrition     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-26     Completed Date:  2005-03-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  390-3     Citation Subset:  IM    
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Dinoprostone / analysis
Fatty Liver / chemically induced*,  prevention & control*
Linoleic Acids, Conjugated / toxicity*
Liver / chemistry
gamma-Linolenic Acid / administration & dosage*
Reg. No./Substance:
0/Linoleic Acids, Conjugated; 363-24-6/Dinoprostone; 506-26-3/gamma-Linolenic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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