| Gamma-linolenic acid prevents conjugated linoleic acid-induced fatty liver in mice. | |
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MedLine Citation:
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PMID: 15043857 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The present study was done to clarify the mechanism by which conjugated linoleic acid (CLA) induces fatty liver in mice and to attenuate this symptom by adding other dietary fatty acids. METHODS: Mice were given CLA short (12 h) or long (4 wk) term or given CLA with linoleic acid (LA) or gamma-linolenic acid (GLA) in the long term (4 wk). Total lipids, triacylglycerol, and prostaglandin E(2) (PGE(2)) levels in the liver were determined. RESULTS: A single administration of CLA significantly increased PGE(2) levels in the liver 12 h after administration. However, long-term administration of CLA significantly decreased the liver PGE(2) level and induced fatty liver. GLA increased PGE(2) levels, and coadministration with GLA, but not with LA, prevented the CLA-induced fatty liver. CONCLUSIONS: These data suggest that CLA initially stimulates PGE(2) production followed by depletion of PGE(2) sources in the liver. The fatty liver associated with PGE(2) reduction by CLA ingestion can be attenuated by GLA in mice. |
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Authors:
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Tomonori Nakanishi; Daichi Oikawa; Tomoyuki Koutoku; Hachidai Hirakawa; Yasuhiro Kido; Tetsuya Tachibana; Mitsuhiro Furuse |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nutrition (Burbank, Los Angeles County, Calif.) Volume: 20 ISSN: 0899-9007 ISO Abbreviation: Nutrition Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-03-26 Completed Date: 2005-03-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8802712 Medline TA: Nutrition Country: United States |
Other Details:
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Languages: eng Pagination: 390-3 Citation Subset: IM |
Affiliation:
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Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dinoprostone / analysis Fatty Liver / chemically induced*, prevention & control* Kinetics Linoleic Acids, Conjugated / toxicity* Liver / chemistry Male Mice gamma-Linolenic Acid / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Linoleic Acids, Conjugated; 363-24-6/Dinoprostone; 506-26-3/gamma-Linolenic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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