Document Detail


Gamma knife radiosurgery for prolactinomas.
MedLine Citation:
PMID:  11143231     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECT: In this retrospective investigation the authors examined the results of gamma knife radiosurgery (GKS) for tumor remnants after unsuccessful open surgery and medical treatment in 20 patients with prolactinomas. Particular attention is paid to a possible radioprotective action of dopamine agonists similar to the action of octreotide in acromegaly. METHODS: Twenty patients with prolactinomas were followed after GKS. Five patients were treated successfully; their prolactin (PRL) levels dropped into the normal range and dopaminergic drugs could be discontinued. Two spontaneous pregnancies were observed and 11 patients experienced improvement. Improvement was defined as normal PRL levels with the continued possibility of reduced medical treatment or a substantially reduced medical treatment dose with some degree of hyperprolactinemia maintained. The treatment failed in three patients who experienced no improvement. Patients treated with dopaminergic drugs during GKS did significantly less well in comparison with the untreated group when a cumulative distribution function (Kaplan-Meier estimate) was used. CONCLUSIONS: The results of GKS for prolactinomas in this investigation are better than the results published by others. This may be an effect of case selection because there were no "salvage cases" in our group of patients. Because a dopamine agonist seemed to induce radioprotection in this series, it is suggested that GKS be performed during an intermission in drug therapy when the dopamine agonist is discontinued.
Authors:
A M Landolt; N Lomax
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  93 Suppl 3     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-15     Completed Date:  2001-01-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14-8     Citation Subset:  AIM; IM    
Affiliation:
Gamma Knife Center, Klinik im Park, Zürich, Switzerland. 100023.1666@compuserve.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Combined Modality Therapy
Dopamine Agonists / administration & dosage
Female
Follow-Up Studies
Humans
Male
Middle Aged
Neoplasm, Residual / blood,  surgery*
Pituitary Neoplasms / blood,  surgery*
Pregnancy
Prolactin / blood
Prolactinoma / blood,  surgery*
Radiosurgery*
Reoperation
Retrospective Studies
Treatment Outcome
Chemical
Reg. No./Substance:
0/Dopamine Agonists; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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