| Gamma-hydroxybutyric acid in the treatment of alcohol and heroin dependence. | |
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MedLine Citation:
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PMID: 10869867 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We briefly review two double-blind, placebo-controlled surveys conducted in this laboratory with the aim of evaluating the efficacy of gamma-hydroxybutyric acid in the treatment of alcohol withdrawal syndrome as well as alcohol craving and consumption in alcoholics. In the first study, acute administration of 50 mg/kg gamma-hydroxybutyric acid, a nonhypnotic dose in alcoholic patients, resulted in a rapid and significant reduction of the severity score of alcohol withdrawal signs and symptoms that lasted as long as 7 hours. In the second study, treatment with 50 mg/kg/day gamma-hydroxybutyric acid for 3 consecutive months (1) reduced the number of daily drinks by approximately 50%, (2) increased the days of abstinence approximately threefold, and (3) reduced the alcohol craving score by up to 60%. These results feature gamma-hydroxybutyric acid as an effective agent for the treatment of alcohol dependence. Data on the effect of gamma-hydroxybutyric acid on opiate withdrawal syndrome also are reviewed. Administration of 25 mg/kg induced a marked reduction of opiate withdrawal score in both heroin- and methadone-dependent subjects. Finally, we report the cases of adverse reactions to and abuse of gamma-hydroxybutyric acid revealed in a retrospective analysis of patients recruited in this laboratory over a 10-year period. |
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Authors:
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L Gallimberti; M R Spella; C A Soncini; G L Gessa |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Alcohol (Fayetteville, N.Y.) Volume: 20 ISSN: 0741-8329 ISO Abbreviation: Alcohol Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-08-11 Completed Date: 2000-08-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502311 Medline TA: Alcohol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 257-62 Citation Subset: IM |
Affiliation:
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Department of Medical and Surgical Sciences, Addictive Medicine Unit, University of Padua, Via Giustiniani 2, I-35100, Padua, Italy. l.gallimberti@libero.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alcoholism
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drug therapy* Clinical Trials as Topic Heroin Dependence / drug therapy* Humans Hydroxybutyrates / administration & dosage, adverse effects, therapeutic use* Substance Withdrawal Syndrome / drug therapy Substance-Related Disorders |
| Chemical | |
Reg. No./Substance:
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0/Hydroxybutyrates; 591-81-1/4-hydroxybutyric acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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