Document Detail

Gamma hydroxybutyrate in the monkey. I. Electroencephalographic, behavioral, and pharmacokinetic studies.
MedLine Citation:
PMID:  97574     Owner:  NLM     Status:  MEDLINE    
Gamma hydroxybutyrate (GHB) was administered to adult and prepubescent rhesus monkeys intravenously in varying dosages while an electroencephalogram (EEG) was recorded from scalp electrodes and the body core temperature was monitored. Blood and cerebrospinal fluid samples were assayed for gamma hydroxybutyrate. GHB produced a trancelike stupor in all the monkeys, associated with marked EEG changes and hypothermia. There was a striking age specificity in that prepubescent rhesus monkeys responded to a lower threshold dosage, had a higher incidence of myoclonic jerking, and showed characteristic EEG changes not seen in the adult animals. The EEG-behavioral changes paralleled the hypothermia. There was good correlation between the serum levels of GHB and the EEG-behavioral effects. These studies suggest that the GHB-treated monkey may have utility as a petit mal seizure model.
O C Snead
Related Documents :
24149454 - Lung diffusion capacity can predict maximal exercise in apparently healthy heavy smokers.
6522194 - Influence of instructions and cognitive articulation on reducing the müller-lyer illusi...
21277504 - Sensory retraining: a cognitive behavioral therapy for altered sensation.
16231344 - An update on the definition of "excessive exercise" in eating disorders research.
1575184 - Efficacy of a single dose of slow-release isosorbide dinitrate in the treatment of sile...
8851904 - Muscle substrate utilization from alveolar gas exchange in trained cyclists.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurology     Volume:  28     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1978 Jul 
Date Detail:
Created Date:  1978-09-25     Completed Date:  1978-09-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  636-42     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Behavior, Animal / drug effects*
Body Temperature / drug effects
Disease Models, Animal
Epilepsy, Absence / chemically induced
Hydroxybutyrates / administration & dosage,  metabolism,  pharmacology*
Injections, Intravenous
Macaca mulatta
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Extracranial vertebral aneurysm with neurofibromatosis.
Next Document:  Gamma hydroxybutyrate in the monkey. II. Effect of chronic oral anticonvulsant drugs.