Document Detail


Gamma hydroxybutyrate in the monkey. I. Electroencephalographic, behavioral, and pharmacokinetic studies.
MedLine Citation:
PMID:  97574     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gamma hydroxybutyrate (GHB) was administered to adult and prepubescent rhesus monkeys intravenously in varying dosages while an electroencephalogram (EEG) was recorded from scalp electrodes and the body core temperature was monitored. Blood and cerebrospinal fluid samples were assayed for gamma hydroxybutyrate. GHB produced a trancelike stupor in all the monkeys, associated with marked EEG changes and hypothermia. There was a striking age specificity in that prepubescent rhesus monkeys responded to a lower threshold dosage, had a higher incidence of myoclonic jerking, and showed characteristic EEG changes not seen in the adult animals. The EEG-behavioral changes paralleled the hypothermia. There was good correlation between the serum levels of GHB and the EEG-behavioral effects. These studies suggest that the GHB-treated monkey may have utility as a petit mal seizure model.
Authors:
O C Snead
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurology     Volume:  28     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1978 Jul 
Date Detail:
Created Date:  1978-09-25     Completed Date:  1978-09-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  636-42     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / drug effects*
Body Temperature / drug effects
Disease Models, Animal
Electroencephalography*
Epilepsy, Absence / chemically induced
Haplorhini
Hydroxybutyrates / administration & dosage,  metabolism,  pharmacology*
Injections, Intravenous
Macaca mulatta
Chemical
Reg. No./Substance:
0/Hydroxybutyrates

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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