Document Detail


Gamma-glutamyltransferase in alcohol use disorders: Modification of decision limits in relation to treatment goals?
MedLine Citation:
PMID:  19929269     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum gamma-glutamyltransferase (GGT) is recommended as a marker for alcohol use disorders by the Swedish National Guidelines for Addiction, although it has a low sensitivity and specificity. GGT is inexpensive and easily accessible but additional knowledge is required on how to use the marker in patients with various levels of alcohol intake. Levels of GGT were obtained from 37 male social drinkers (< 100 grams pure alcohol weekly) and 18 former alcohol-dependent males with long-term (6 +/- 5 years) abstinence. Reproducibility was calculated through repeated blood samplings. Mean serum activity of GGT, in former alcohol-dependent males, was 0.26 microkat/L with an intra-class correlation coefficient of 0.85. In social drinkers, these figures were 0.34 microkat/L and 0.92, respectively. In treatment of males, with the goal of abstinence, upper reference limit is suggested to be 0.40 microkat/L. Goals of non-harmful drinking (< 100 grams weekly) suggest higher limits (0.62 microkat/L). Thirty percent increase of GGT should be suggestive of relapse.
Authors:
Jan Balldin; Ulf Berggren; Kristina Berglund; Kaj Blennow; Claudia Fahlke; Henrik Zetterberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  70     ISSN:  1502-7686     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-19     Completed Date:  2010-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  England    
Other Details:
Languages:  eng     Pagination:  71-4     Citation Subset:  IM    
Affiliation:
Institute of Clinical Neuroscience, Section of Psychiatry, Sahlgrenska Academy at Göteborg University Sweden, Göteborg, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohol Drinking / blood
Alcohol-Related Disorders / blood*,  diagnosis*,  enzymology
Humans
Male
Middle Aged
Recurrence
Reference Values
Reproducibility of Results
Young Adult
gamma-Glutamyltransferase / blood*
Chemical
Reg. No./Substance:
EC 2.3.2.2/gamma-Glutamyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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