| Gamma-glutamyltransferase, cardiovascular disease and mortality in individuals with diabetes mellitus. | |
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MedLine Citation:
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PMID: 22144398 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Increased plasma-activity of gamma-glutamyltransferase (GGT) is associated with cardiovascular diseases (CVD) and mortality in the general population. We investigated the association between GGT, CVD and mortality in individuals with diabetes mellitus. METHODS: Data was used from 1,280 participants, aged 35-70 years, with a confirmed diagnosis of diabetes mellitus in the European Prospective Investigation into Cancer and Nutrition in Potsdam (Germany), Bilthoven and Utrecht (the Netherlands). Multivariate Hazard Ratios (HR) and 95% confidence intervals (CI) for CVD (non-fatal and fatal events) and overall mortality were estimated using sex-specific quartiles of GGT. RESULTS: After 8.2 y follow-up, 108 incident CVD cases and 84 deaths were observed. Participants with high GGT activity had an increased mortality risk: HR in the highest quartile was 3.96 (95% CI 1.74, 9.00). This association was in particular present in former and current smokers, younger persons, and those with a higher waist-height ratio and alcohol consumption. No associations were observed for non-fatal CVD and non-fatal and fatal CVD events combined. CONCLUSIONS: Higher GGT plasma-activity is associated with increased all-cause mortality in individuals with diabetes. Copyright © 2011 John Wiley & Sons, Ltd. |
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Authors:
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Diewertje Sluik; Joline W J Beulens; Cornelia Weikert; Susan van Dieren; Annemieke M W Spijkerman; Daphne L van der A; Andreas Fritsche; Hans-Georg Joost; Heiner Boeing; Ute Nöthlings |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-5 |
Journal Detail:
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Title: Diabetes/metabolism research and reviews Volume: - ISSN: 1520-7560 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883450 Medline TA: Diabetes Metab Res Rev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany. Diewertje.Sluik@dife.de. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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