| Gamma-glutamyl compounds and their enzymatic production using bacterial gamma-glutamyltranspeptidase. | |
| | |
MedLine Citation:
|
PMID: 17031476 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Some amino acids and peptides, which have low solubility in water, become much more soluble following gamma-glutamylation. Compounds become more stable in the blood stream with gamma-glutamylation. Several gamma-glutamyl compounds are known to have favorable physiological effects on mammals. Gamma-glutamylation can improve taste and can stabilize glutamine in aqueous solution. Because of such favorable features, gamma-glutamyl compounds are very attractive. However, only a small number of gamma-glutamyl amino acids have been studied although many other gamma-glutamyl compounds may have characteristics that will benefit humans. This is mainly because gamma-glutamyl compounds have not been readily available. An efficient and simple method of producing various gamma-glutamyl compounds, especially gamma-glutamyl amino acids, using bacterial gamma-glutamyltranspeptidase has been developed. With this method, modifications of reactive groups of the substrate and energy source such as ATP are not required, and a wide-range of gamma-glutamyl compounds can be synthesized. Moreover, bacterial gamma-glutamyltranspeptidase, a catalyst for this method, is readily available from the strain over-producing this enzyme. The superiority of producing gamma-glutamyl compounds with bacterial gamma-glutamyltranspeptidase over other methods of production is discussed. |
| | |
Authors:
|
H Suzuki; C Yamada; K Kato |
Related Documents
:
|
1696366 - Spermine and philanthotoxin potentiate excitatory amino acid responses of xenopus oocyt... 2867926 - Changes in gamma-aminobutyrate, glutamate, aspartate, glycine, and taurine contents in ... 21112316 - Attenuation of proinflammatory cytokines and apoptotic process by verapamil and diltiaz... 16791106 - Stability of substantia nigra pars reticulata neuronal discharge rates during dopamine ... 16883366 - The evidence for efficacy of omega-3 fatty acids in preventing or slowing the progressi... 19650106 - Undecylenic acid: a valuable and physiologically active renewable building block from c... |
Publication Detail:
|
Type: Journal Article; Review Date: 2006-10-13 |
Journal Detail:
|
Title: Amino acids Volume: 32 ISSN: 0939-4451 ISO Abbreviation: Amino Acids Publication Date: 2007 |
Date Detail:
|
Created Date: 2007-04-09 Completed Date: 2007-09-14 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9200312 Medline TA: Amino Acids Country: Austria |
Other Details:
|
Languages: eng Pagination: 333-40 Citation Subset: IM |
Affiliation:
|
Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan. hideyuki@lif.kyoto-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bacteria / chemistry, enzymology* Bacterial Proteins / chemistry, metabolism* Catalysis Glutamine / analogs & derivatives*, biosynthesis*, chemistry Humans Peptide Biosynthesis, Nucleic Acid-Independent* Peptides / chemistry, metabolism* gamma-Glutamyltransferase / chemistry, metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Bacterial Proteins; 0/Peptides; 56-85-9/Glutamine; EC 2.3.2.2/gamma-Glutamyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cellular thiol status-dependent inhibition of tumor cell growth via modulation of p27(kip1) transloc...
Next Document: Multi-layered network structure of amino acid (AA) metabolism characterized by each essential AA-def...