Document Detail

Gamma, but not alpha, tocopherol levels in serum are reduced in coronary heart disease patients.
MedLine Citation:
PMID:  8568478     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Low concentrations of alpha tocopherol are claimed to be associated with an increased prevalence of coronary heart disease. This study was undertaken to see whether measurements of serum tocopherol concentrations can contribute to discrimination between subjects with and without coronary heart disease. SETTING: All patients had been referred to the department of cardiology of the University Hospital in Uppsala, Sweden. SUBJECTS: Male patients (n = 69) below 60 years of age with coronary heart disease (CHD) and healthy age-matched reference subjects (n = 138) were compared. RESULTS: Lipid-corrected alpha tocopherol concentrations did not differ significantly between the groups, but the CHD group had a lower mean concentration of gamma tocopherol and a higher alpha/gamma ratio. In a stepwise logistic regression analysis, the LDL/HDL ratio was the best independent discriminator between the groups, followed by the proportion of palmitic acid in the cholesterol esters and the alpha/gamma tocopherol ratio. CONCLUSIONS: The lower gamma tocopherol concentration and the high ratio between alpha and gamma tocopherol in the CHD group indicate a difference in antioxidative status between CHD patients and healthy subjects. The lipid-lowering treatment of these CHD patients is far from optimal.
M Ohrvall; G Sundl?f; B Vessby
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of internal medicine     Volume:  239     ISSN:  0954-6820     ISO Abbreviation:  J. Intern. Med.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-03-05     Completed Date:  1996-03-05     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  111-7     Citation Subset:  IM    
Department of Geriatrics, University of Uppsala, Sweden.
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MeSH Terms
Case-Control Studies
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Coronary Disease / blood*
Lipids / blood
Logistic Models
Middle Aged
Palmitic Acid
Palmitic Acids / blood
Vitamin E / blood*
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipids; 0/Palmitic Acids; 1406-18-4/Vitamin E; 57-10-3/Palmitic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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