| Gamma-aminobutyric acid and the high pressure neurological syndrome. | |
| | |
MedLine Citation:
|
PMID: 3090469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Sodium valproate, nipecotic acid, diaminobutyric acid (DABA) and beta-alanine are drugs which enhance transmission mediated by gamma-aminobutyric acid (GABA) by a variety of mechanisms. They were used to study the role of GABA in the high pressure neurological syndrome (HPNS) in the rat. Sodium valproate, nipecotic acid and DABA reduced the increase in slow waves seen in the electroencephalogram (EEG) of control rats at pressures above 10-20 ATA; however, only sodium valproate had a beneficial effect on the behavioural signs of the high pressure neurological syndrome (tremor, myoclonus and convulsions). Sodium valproate is also thought to decrease neurotransmission produced by excitatory amino acids; thus, these results suggest that GABA is not one of the major neurotransmitters involved in all aspects of the high pressure neurological syndrome and that changes in excitatory neurotransmission may affect the behavioural signs. |
| | |
Authors:
|
J C Rostain; B Wardley-Smith; C Forni; M J Halsey |
Related Documents
:
|
16517729 - Signaling through mutants of the iga receptor cd89 and consequences for fc receptor gam... 7116229 - Excitability of primary afferents in feline spinal cord: taurine, homotaurine, and gamm... 1293019 - Effect of diethylcarbamazine on acetylcholine and gamma amino butyric acid in setaria d... 6127409 - Drug latentiation by gamma-glutamyl transpeptidase. 10552779 - Synthesis and characterization of gamma-n-(2-furoylmethyl)aminobutyric acid. 11520129 - Audiogenic seizure susceptibility is induced by termination of continuous infusion of g... 16806909 - Enhanced production of scleroglucan by sclerotium rolfsii mtcc 2156 by use of metabolic... 19362649 - Bacterial fatty acid synthesis and its relationships with polyketide synthetic pathways. 10331659 - Long chain fatty acids as modulators of gene transcription in preadipose cells. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Neuropharmacology Volume: 25 ISSN: 0028-3908 ISO Abbreviation: Neuropharmacology Publication Date: 1986 May |
Date Detail:
|
Created Date: 1986-09-16 Completed Date: 1986-09-16 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0236217 Medline TA: Neuropharmacology Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 545-54 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alanine
/
pharmacology Aminobutyric Acids / pharmacology Animals Atmospheric Pressure Central Nervous System Diseases / physiopathology* Electrodes, Implanted Electroencephalography High Pressure Neurological Syndrome / physiopathology* Male Myoclonus / physiopathology Nipecotic Acids / pharmacology Proline* / analogs & derivatives* Rats Rats, Inbred Strains Tremor / physiopathology Valproic Acid / pharmacology gamma-Aminobutyric Acid / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Aminobutyric Acids; 0/Nipecotic Acids; 147-85-3/Proline; 305-62-4/2,4-diaminobutyric acid; 498-95-3/nipecotic acid; 56-12-2/gamma-Aminobutyric Acid; 56-41-7/Alanine; 56879-46-0/homoproline; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of barbiturates on energy metabolism by cultured astrocytes and neurons in the presence of n...
Next Document: Three uptake systems in synaptosomes for nipecotic acid and beta-alanine.