| Gamma-aminobutyric acid antagonism and presynaptic inhibition in the frog spinal cord. | |
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MedLine Citation:
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PMID: 4332628 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The convulsant alkaloid bicuculline blocked presynaptic inhibition, dorsal root potentials, primary afferent depolarization, and depolarizing effects of gamma-aminobutyric acid on dorsal root terminals of the amphibian spinal cord, but did not block effects of other putative amino acid transmitters. These actions of bicuculline suggest that gamma-aminobutyric acid may be the transmitter involved in spinal presynaptic inhibition. |
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Authors:
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R A Davidoff |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 175 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1972 Jan |
Date Detail:
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Created Date: 1972-03-24 Completed Date: 1972-03-24 Revised Date: 2011-12-27 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 331-3 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials Alkaloids / pharmacology* Aminobutyric Acids / antagonists & inhibitors*, pharmacology Animals Anura Dioxoles / pharmacology Drug Interactions Electric Stimulation Electrodes Evoked Potentials Glutamates / antagonists & inhibitors, pharmacology Isoquinolines / pharmacology* Neuromuscular Depolarizing Agents / antagonists & inhibitors, pharmacology Neurons, Afferent / drug effects Rana pipiens Reflex Spinal Cord / drug effects Synapses / drug effects* Synaptic Transmission / drug effects* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Alkaloids; 0/Aminobutyric Acids; 0/Dioxoles; 0/Glutamates; 0/Isoquinolines; 0/Neuromuscular Depolarizing Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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