Document Detail


Gamma-aminobutyrate: defense against invertebrate pests?
MedLine Citation:
PMID:  16890474     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gamma-aminobutyrate (GABA) is a ubiquitous four-carbon, non-protein amino acid. In plants, stress-induced GABA accumulation is well documented. However, the role(s) of GABA accumulation is contentious. In this Opinion article, we argue that wounding due to herbivory and crawling by insect larvae causes rapid GABA accumulation via the disruption of cellular compartmentation and the release of the acidic vacuolar contents to the cytosol. The activity of glutamate decarboxylase, the cytosolic enzyme responsible for GABA synthesis, has an acidic pH optimum. Subsequent GABA ingestion has a plant defense function by directly acting on GABA-regulated invertebrate neuromuscular junctions. Plants with an enhanced GABA-producing capacity reduce herbivory by invertebrate pests. These findings suggest that GABA accumulation is a rapidly deployed, local resistance mechanism that constitutes a first line of defense in deterring herbivory.
Authors:
Alan W Bown; Kennaway B Macgregor; Barry J Shelp
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-08-04
Journal Detail:
Title:  Trends in plant science     Volume:  11     ISSN:  1360-1385     ISO Abbreviation:  Trends Plant Sci.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-28     Completed Date:  2006-12-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9890299     Medline TA:  Trends Plant Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  424-7     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, Brock University, St. Catharines, Ontario, L2S 3A9, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chloride Channels / metabolism
Insects / metabolism
Larva / metabolism
Neuromuscular Junction / metabolism
Plants / metabolism*,  parasitology*
gamma-Aminobutyric Acid / metabolism*
Chemical
Reg. No./Substance:
0/Chloride Channels; 56-12-2/gamma-Aminobutyric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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