| Gamma and alpha motor neurons distinguished by expression of transcription factor Err3. | |
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MedLine Citation:
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PMID: 19651609 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Spinal motor neurons are specified to innervate different muscle targets through combinatorial programs of transcription factor expression. Whether transcriptional programs also establish finer aspects of motor neuron subtype identity, notably the prominent functional distinction between alpha and gamma motor neurons, remains unclear. In this study, we identify DNA binding proteins with complementary expression profiles in alpha and gamma motor neurons, providing evidence for molecular distinctions in these two motor neuron subtypes. The transcription factor Err3 is expressed at high levels in gamma but not alpha motor neurons, whereas the neuronal DNA binding protein NeuN marks alpha but not gamma motor neurons. Signals from muscle spindles are needed to support the differentiation of Err3(on)/NeuN(off) presumptive gamma motor neurons, whereas direct proprioceptive sensory input to a motor neuron pool is apparently dispensable. Together, these findings provide evidence that transcriptional programs define functionally distinct motor neuron subpopulations, even within anatomically defined motor pools. |
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Authors:
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Andreas Friese; Julia A Kaltschmidt; David R Ladle; Markus Sigrist; Thomas M Jessell; Silvia Arber |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-27 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 106 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-26 Completed Date: 2009-09-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 13588-93 Citation Subset: IM |
Affiliation:
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Biozentrum, Department of Cell Biology, University of Basel and Friedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers / metabolism Mice Motor Neurons / enzymology, metabolism*, pathology Muscle Spindles / metabolism, pathology Neuraminidase / metabolism Neurons, Afferent / metabolism, pathology Phenotype Proprioception Receptors, Estrogen / metabolism* Transcription Factors / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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IPTRF 064871//Wellcome Trust; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Esrrg protein, mouse; 0/Receptors, Estrogen; 0/Transcription Factors; EC 3.2.1.18/Neuraminidase |
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