Document Detail

Gamma Knife surgery for cerebral arteriovenous malformations in children: a 13-year experience.
MedLine Citation:
PMID:  18377305     Owner:  NLM     Status:  MEDLINE    
OBJECT: Studies on the efficacy of arteriovenous malformation (AVM) radiosurgery have largely been conducted in the adult population. Clinically, the results may not always be applicable to pediatric patients. Moreover, studies involving the pediatric population have largely comprised small- (< 3 cm3) and medium-sized (3-10 cm3) AVMs. For large (> 10 cm3) AVMs in children, sparse radiosurgical results are available. The current study was conducted to further clarify the role of radiosurgery in the treatment of pediatric AVMs. METHODS: A retrospective analysis was performed of data obtained in 105 pediatric patients (< 18 years of age) with cerebral AVMs treated by Gamma Knife surgery (GKS) between 1993 and 2006. For statistical comparison the authors studied data acquired in 458 adult patients with AVMs treated during the same period. The patients underwent follow-up magnetic resonance imaging at 6-month intervals. Cerebral angiography was used to confirm the obliteration of the AVM. RESULTS: In pediatric patients, the AVM obliteration rate at 48 months after a primary GKS was 65%. Repeated GKS in those in whom primary treatments failed further ablated some AVMs, for an overall obliteration rate of 81%. The efficacy of GKS correlated with the size of the AVM: 91% for small, 86% for medium, and 64% for large AVMs. The treatments were associated with an 8% morbidity rate and < 1% mortality rate. Posttreatment hemorrhage occurred in 4 (4%) of 105 patients. Obliteration rates at 48 months of small and extremely large (> 20 cm3) AVMs were similar in the pediatric and adult groups, whereas AVMs between 3 and 10 cm3 responded less efficaciously in children (p = 0.042). The AVMs with volumes ranging from 10 to 20 cm3 were also associated with a lower obliteration rate in children at 48 months, but statistical significance was not reached (p = 0.279). CONCLUSIONS: Gamma Knife surgery is an effective and safe treatment alternative for pediatric AVMs. The medium (3-10-cm3) and large (10-20-cm3) AVMs tend to respond less efficaciously than those of comparable size in adults.
David Hung-Chi Pan; Yu-Hung Kuo; Wan-Yuo Guo; Wen-Yuh Chung; Hsiu-Mei Wu; Kang-Du Liu; Yue-Cune Chang; Ling-Wei Wang; Tai-Tong Wong
Related Documents :
18551935 - Primary intracerebral haemorrhage in malaysia: in-hospital mortality and outcome in pat...
24621725 - Skeletal stability and complications in transantral maxillary distraction in patients w...
3434025 - Clinical course and surgical results in supratentorial low-grade gliomas.
18377305 - Gamma knife surgery for cerebral arteriovenous malformations in children: a 13-year exp...
20345885 - Second-line treatment in the malawi antiretroviral programme: high early mortality, but...
2368435 - Clinical significance of associated nodular lesions of the adrenal in patients with ald...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgery. Pediatrics     Volume:  1     ISSN:  1933-0707     ISO Abbreviation:  -     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-01     Completed Date:  2008-05-20     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  101463759     Medline TA:  J Neurosurg Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  296-304     Citation Subset:  IM    
Department of Neurosurgery, Taipei Veterans General Hospital, Taipei, Taiwan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cerebral Angiography
Child, Preschool
Follow-Up Studies
Intracranial Arteriovenous Malformations / surgery*
Magnetic Resonance Imaging
Postoperative Complications
Radiosurgery* / methods
Retrospective Studies
Treatment Outcome
Comment In:
J Neurosurg Pediatr. 2008 Sep;2(3):229; author reply 229   [PMID:  18759608 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cerebrospinal fluid eosinophilia in children with ventricular shunts.
Next Document:  Expression of MAGE and GAGE genes in medulloblastoma and modulation of resistance to chemotherapy. L...