Document Detail

Gamma Knife stereotactic radiosurgical treatment of idiopathic trigeminal neuralgia: long-term outcome and complications.
MedLine Citation:
PMID:  18081485     Owner:  NLM     Status:  MEDLINE    
OBJECT: Stereotactic radiosurgery (SRS) with the Gamma Knife (GK) is a rapidly emerging surgical modality in the management of medically refractory idiopathic trigeminal neuralgia (TN). The current study examines the long-term outcome in patients with drug-resistant idiopathic TN who underwent GK surgery at the authors' institution. METHODS: One hundred and six consecutive patients (38 men and 68 women) with proven medically refractory idiopathic TN were included in this retrospective study. Their ages were 41-82 years (mean 72.3 years). All patients underwent SRS with prescribed maximal radiation doses ranging from 70 to 85 Gy. Isocenters 1-3 were used and plugging was used selectively. The follow-up period was 12-72 months (mean 34.3 months). The patients were divided into 2 groups according to their history of previous surgery. RESULTS: The initial response rate in patients with no history of previous surgery was 92.9%; in those who had undergone previous surgery, the initial response rate was 85.7%. At the end of the 1st posttreatment year, an excellent outcome was achieved in 82.5% of patients who had not had previous surgery, and in 69.4% of those who had. The respective outcome rates for the 2nd posttreatment year were 78 and 63.5%, respectively. The most common complication was the development of persistent paresthesia, which occurred in 15.8% of patients with no previous surgery and 16.3% of those with previous surgery. CONCLUSIONS: Stereotactic radiosurgery with the GK is a safe and effective treatment option for patients with medically refractory idiopathic TN.
Kostas N Fountas; Joseph R Smith; Gregory P Lee; Patrick D Jenkins; Rebecca R Cantrell; W Chris Sheils
Related Documents :
3670575 - Staged treatment of arteriovenous malformations of the brain.
4069325 - Cranial chordomas: clinical presentation and results of operative and radiation therapy...
20452785 - Neurosurgical outcomes after intracerebral hemorrhage: results of the factor seven for ...
2261405 - Radiation therapy for symptomatic vertebral haemangioma.
12699475 - The role of capsaicin-sensitive afferents in autonomic dysreflexia in patients with spi...
1774655 - Hyperopic thermokeratoplasty: clinical evaluation.
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Neurosurgical focus     Volume:  23     ISSN:  1092-0684     ISO Abbreviation:  Neurosurg Focus     Publication Date:  2007  
Date Detail:
Created Date:  2007-12-17     Completed Date:  2008-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100896471     Medline TA:  Neurosurg Focus     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E8     Citation Subset:  IM    
Departments of Neurosurgery, Medical College of Georgia, Augusta, Georgia, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Follow-Up Studies
Middle Aged
Pain Measurement
Prospective Studies
Radiosurgery / methods*
Retrospective Studies
Treatment Outcome*
Trigeminal Neuralgia / radiotherapy*,  surgery*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Advances in the radiosurgical treatment of large inoperable arteriovenous malformations.
Next Document:  CyberKnife radiosurgical rhizotomy for the treatment of atypical trigeminal nerve pain.