Document Detail


Gamma Knife radiosurgery for trigeminal neuralgia: the impact of magnetic resonance imaging-detected vascular impingement of the affected nerve.
MedLine Citation:
PMID:  19852545     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECT: Trigeminal neuralgia is believed to be related to vascular compression of the affected nerve. Radiosurgery has been shown to be reasonably effective for treatment of medically refractory trigeminal neuralgia. This study explores the rate of occurrence of MR imaging-demonstrated vascular impingement of the affected nerve and the extent to which vascular impingement affects pain relief in a population of trigeminal neuralgia patients undergoing Gamma Knife radiosurgery (GKRS). METHODS: The authors performed a retrospective analysis of 106 cases involving patients treated for typical trigeminal neuralgia using GKRS. Patients with or without single-vessel impingement on CISS MR imaging sequences and with no previous surgery were included in the study. Pain relief was assessed according to the Barrow Neurological Institute (BNI) pain intensity score at the last follow-up. Degree of impingement, nerve diameter preand post-impingement, isocenter placement, and dose to the point of maximum impingement were evaluated in relation to the improvement of BNI score. RESULTS: The overall median follow-up period was 31 months. Overall, a BNI pain score of 1 was achieved in 59.4% of patients at last follow-up. Vessel impingement was seen in 63 patients (59%). There was no significant difference in pain relief between those with and without vascular impingement following GKRS (p > 0.05). In those with vascular impingement on MR imaging, the median fraction of vessel impingement was 0.3 (range 0.04-0.59). The median dose to the site of maximum impingement was 42 Gy (range 2.9-79 Gy). Increased dose (p = 0.019) and closer proximity of the isocenter to the site of maximum vessel impingement (p = 0.012) correlated in a statistically significant fashion with improved BNI scores in those demonstrating vascular impingement on the GKRS planning MR imaging. CONCLUSIONS: Vascular impingement of the affected nerve was seen in the majority of patients with trigeminal neuralgia. Overall pain relief following GKRS was comparable in those with and without evidence of vascular compression on MR imaging. In subgroup analysis of those with MR imaging evidence of vessel impingement of the affected trigeminal nerve, pain relief correlated with a higher dose to the point of contact between the impinging vessel and the trigeminal nerve. Such a finding may point to vascular changes affording at least some degree of relief following GKRS for trigeminal neuralgia.
Authors:
Jason P Sheehan; Dibyendu Kumar Ray; Stephen Monteith; Chun Po Yen; James Lesnick; Ronald Kersh; David Schlesinger
Related Documents :
16402625 - Feature-based detection of facial landmarks from neutral and expressive facial images.
22820005 - Simulation and analysis of the interactions between split gradient coils and a split ma...
1768655 - Prandial presbyopia: the muffin man.
11254765 - Magnetic resonance imaging, magnetisation transfer imaging, and diffusion weighted imag...
18300005 - "unertan syndrome" in two turkish families in relation to devolution and emergence of h...
22926555 - An nmr metabolomics approach for the diagnosis of leptomeningeal carcinomatosis.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  113     ISSN:  1933-0693     ISO Abbreviation:  J. Neurosurg.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-02     Completed Date:  2010-07-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  53-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA. jps2f@virginia.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Female
Humans
Magnetic Resonance Imaging*
Male
Middle Aged
Nerve Compression Syndromes / diagnosis,  surgery*
Neuronavigation*
Pain Measurement
Radiosurgery*
Retrospective Studies
Treatment Outcome
Trigeminal Nerve / pathology,  surgery*
Trigeminal Neuralgia / diagnosis,  surgery*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Toll-like receptor 4 expression during cerebral aneurysm formation. Laboratory investigation.
Next Document:  Effect of diesel exhaust inhalation on antioxidant and oxidative stress responses in adults with met...