| Gamiwalbitang, composed of four herbs, controls body weight increase and lipid level elevation induced by a high-fat diet in mice. | |
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MedLine Citation:
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PMID: 20136469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gamiwalbitang (GWB) is a newly developed dietary supplement that is composed of four herbs. The purpose of GWB development is to help control weight. The aim of this study was to investigate whether GWB combined with a 40% high-fat (HF) diet can influence body weight and fat accumulation. An experiment was conducted with 40 C57BL/6J mice with an initial body weight of approximately 18g. Body weight was recorded weekly, and plasma levels of triglyceride, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and leptin were analyzed at the end of the study. Weight increases in the 10% GWB group were 38.5% less than in the HF diet group (P < 0.05). Plasma triglyceride and LDL cholesterol levels decreased by 21.2% and 51.0%, respectively, in the 5% GWB group, and 44.1% and 51.5%, respectively, in the 10% GWB group compared to the HF diet group. The HDL cholesterol level was increased by 184.0% in the 5% GWB group and 188.2% in the 10% GWB group. The serum leptin level was significantly decreased by the GWB diet, and in the GWB diet group; gene expression of leptin in adipose tissue was also decreased compared with HF diet group. These findings indicate that GWB may be beneficial in the regulation of high-fat diet-induced blood circulatory disorders. |
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Authors:
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Hyo-Jin An; Hong-Kun Rim; Se-Eun Suh; Hyun-Ja Jeong; Jae-Young Um; Seung-Heon Hong; Hyung-Min Kim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Immunopharmacology and immunotoxicology Volume: 32 ISSN: 1532-2513 ISO Abbreviation: Immunopharmacol Immunotoxicol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-05 Completed Date: 2010-08-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8800150 Medline TA: Immunopharmacol Immunotoxicol Country: England |
Other Details:
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Languages: eng Pagination: 307-12 Citation Subset: IM |
Affiliation:
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College of Oriental Medicine, Institute of Oriental Medicine, Oriental Medical Science Center, Kyung Hee University, Seoul, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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drug effects Animals Anti-Obesity Agents / administration & dosage, pharmacology*, therapeutic use Body Weight / drug effects* Dietary Fats / administration & dosage*, adverse effects Dietary Supplements Enzyme-Linked Immunosorbent Assay Epididymis / drug effects Lipids / blood* Male Mice Mice, Inbred C57BL Obesity / blood, prevention & control* Plant Extracts / administration & dosage, pharmacology*, therapeutic use Plant Preparations / administration & dosage, pharmacology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anti-Obesity Agents; 0/Dietary Fats; 0/Lipids; 0/Plant Extracts; 0/Plant Preparations; 0/gamiwalbitang |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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