| Gambogenic acid inhibits proliferation of A549 cells through apoptosis-inducing and cell cycle arresting. | |
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MedLine Citation:
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PMID: 20190402 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although anticancer effect of gambogic acid (GA) and its potential mechanisms were well documented in past decades, limited information is available on the anticancer effect of gambogenic acid (GNA), another major active component of Gamboge. Here we performed a study to determine whether GNA possesses anticancer effect and find its potential mechanisms. The results suggested that GNA significantly inhibited the proliferation of several tumor cell lines in vitro and in vivo. Treatment with GNA dose and time dependently induced A549 cells apoptosis, arrested the cells to G0/G1 phase in vitro and down-regulated the expression of cyclin D1 and cyclooxygenase (COX)-2 in mRNA level. In addition, anticancer effect was further demonstrated by applying xenografts in nude mice coupled with the characteristic of apoptosis in the GNA treated group. Taken together, these observations might suggest that GNA inhibits tumor cell proliferation via apoptosis-induction and cell cycle arrest. |
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Authors:
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Qinglin Li; Hui Cheng; Guoqi Zhu; Li Yang; An Zhou; Xiaoshan Wang; Nianbai Fang; Lunzhu Xia; Jingjing Su; Mei Wang; Daiying Peng; Qi Xu |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biological & pharmaceutical bulletin Volume: 33 ISSN: 1347-5215 ISO Abbreviation: Biol. Pharm. Bull. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-03-01 Completed Date: 2010-09-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9311984 Medline TA: Biol Pharm Bull Country: Japan |
Other Details:
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Languages: eng Pagination: 415-20 Citation Subset: IM |
Affiliation:
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Anhui Province Key Laboratory of R&D of Chinese Medicine, Anhui Key Laboratory of Modernized Chinese Material, Anhui University of Traditional Chinese Medicine, China. qinglin_lee@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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drug therapy*,
pathology Animals Antineoplastic Agents, Phytogenic / pharmacology*, therapeutic use Apoptosis / drug effects* Cell Cycle / drug effects* Cell Line, Tumor Cell Proliferation / drug effects Cyclin D1 / genetics, metabolism Cyclooxygenase 2 / genetics, metabolism Dose-Response Relationship, Drug Down-Regulation Female Garcinia / chemistry* Gene Expression Regulation Humans Lung Neoplasms / drug therapy*, pathology Male Mice Mice, Inbred BALB C Mice, Nude Phytotherapy Plant Extracts / pharmacology*, therapeutic use RNA, Messenger / metabolism Resins, Plant Terpenes / isolation & purification, pharmacology, therapeutic use* Xanthones / isolation & purification, pharmacology, therapeutic use* Xenograft Model Antitumor Assays |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Plant Extracts; 0/RNA, Messenger; 0/Resins, Plant; 0/Terpenes; 0/Xanthones; 0/gambogenic acid; 136601-57-5/Cyclin D1; EC 1.14.99.1/Cyclooxygenase 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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