Document Detail

Galvanic stimulation in bilateral vestibular failure: 3-D ocular motor effects.
MedLine Citation:
PMID:  10599835     Owner:  NLM     Status:  MEDLINE    
Bilateral galvanic vestibular stimulation (GVS) with current intensity of 3 mA was applied at mastoid level in 11 patients with chronic bilateral vestibular failure, in order to determine ocular motor responses by 3-D video-oculography. The following abnormal features were found: (1) a predominantly torsional or mixed torsional-horizontal nystagmus at the onset of stimulation with lower current intensities (1.0-3.0 mA) in nine patients; (2) a reduced amplitude of tonic ocular torsion by about 50% in nine patients (1.3 +/- 0.6 degrees at 3 mA); (3) a nystagmus in the opposite direction at stimulation offset in five patients (rebound); (4) no eye movements at all in a patient with bilateral nerve failure. GVS stimulates the vestibular nerve, thus allowing differentiation of nerve failure from labyrinthine failure. The low thresholds for initiating nystagmus and the rebound, which appear to be the most typical features of bilateral labyrinthine failure, can be explained by central compensation mechanisms.
M Dieterich; R Zink; A Weiss; T Brandt
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  10     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-02-28     Completed Date:  2000-02-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  3283-7     Citation Subset:  IM; S    
Department of Neurology, Ludwig-Maximilians-University, Klinikum Grosshadern, Munich, Germany.
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MeSH Terms
Electric Stimulation
Eye Movements / physiology*
Functional Laterality / physiology
Middle Aged
Nystagmus, Physiologic / physiology
Oculomotor Muscles / innervation,  physiology*
Reflex, Vestibulo-Ocular / physiology
Semicircular Canals / physiology
Vestibular Diseases / diagnosis,  physiopathology*
Vestibular Function Tests / methods*

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