Document Detail


Gallstones associated with nonalcoholic steatohepatitis (NASH) and metabolic syndrome.
MedLine Citation:
PMID:  21331995     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background/aims: We aimed to evaluate the prevalence of non-alcoholic steatohepatitis and metabolic syndrome in patients with symptomatic gallstones undergoing laparoscopic or open cholecystectomy. Methods: A study of 95 patients was performed. Simultaneous liver biopsies were taken during cholecystectomy between 2006 and 2007. There were no postoperative complications. Patients with significant alcohol intake, hepatitis B or C (virus-positive), autoimmune diseases, and Wilson's disease were excluded. Demographics, liver function tests, lipid profile, and ultrasound findings of patients with and without non-alcoholic steatohepatitis were compared. Results: A total of 95 patients completed the study. The mean age was 52.15 years, and 29 patients were male and 66 female. Fifty-two patients (55%) had biopsies compatible with non-alcoholic steatohepatitis. Conclusions: Fifty-five percent of patients with gallbladder stones had associated non-alcoholic steatohepatitis. Awareness of this association may result in an earlier diagnosis. The high prevalence of non-alcoholic steatohepatitis in patients with galbladder stone may justify routine liver biopsy during cholecystectomy to establish the diagnosis and stage and possibly direct therapy.
Authors:
Oktay Yener; Fikret Aksoy; Mustafa Demır; Alp Ozçelık; Canan Erengül
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology     Volume:  21     ISSN:  1300-4948     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-2-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9515841     Medline TA:  Turk J Gastroenterol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  411-415     Citation Subset:  -    
Affiliation:
Department of Surgery, Göztepe Training and Research Hospital, İstanbul. oktayener@gmail.com.
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