Document Detail

Gallstone dissolution therapy with ursodiol. Patient selection.
MedLine Citation:
PMID:  2598766     Owner:  NLM     Status:  MEDLINE    
Ursodeoxycholic acid (ursodiol) has been shown to be an effective oral agent for dissolution of gallstones that also has a favorable safety profile. In the selection of patients as candidates for this treatment, stone characteristics and the functional status of the gallbladder are the two most important criteria. Small, primarily cholesterol stones (radiolucent on plain film) are the most suitable for oral dissolution therapy. In addition, a functioning gallbladder (as evidenced by visualization on oral cholecystogram) is required to concentrate the ursodiol-enriched bile and effect stone dissolution. Ursodiol should not be used during pregnancy, in women likely to become pregnant, or in severe acute or chronic intrahepatic cholestasis. Acute cholestasis and common bile duct obstruction also preclude this treatment. Screening tests include basic laboratory tests of liver function, sonographic evaluation of the gallbladder and biliary tree, plain film of the abdomen, and oral cholecystogram. Since few patients meet all the selection criteria ideally, the decision to undertake treatment with ursodiol must be based on the entire clinical profile and on the patient's willingness to accept the predicted likelihood of success.
H Fromm
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  34     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-01-29     Completed Date:  1990-01-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  36S-38S     Citation Subset:  AIM; IM    
Department of Medicine, George Washington University, Washington, D.C. 20037.
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MeSH Terms
Age Factors
Body Weight
Cholelithiasis / analysis,  therapy*
Cholesterol / analysis
Deoxycholic Acid / analogs & derivatives*
Gallbladder / physiopathology
Ursodeoxycholic Acid / therapeutic use*
Reg. No./Substance:
128-13-2/Ursodeoxycholic Acid; 57-88-5/Cholesterol; 83-44-3/Deoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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