Document Detail


Gallstone dissolution in methyl tert-butyl ether after mechanical fragmentation: in vitro study.
MedLine Citation:
PMID:  2112866     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty sets of three gallstones matched for weight and appearance were selected from 20 surgically resected human gallbladders to test the effect of intracorporeal mechanical fragmentation on gallstone dissolution with methyl tert-butyl ether in vitro. One stone from each set was fragmented by a mechanical lithotriptor and then treated with methyl tert-butyl ether, and one was used as control and was treated intact. The third stone was analyzed for its density pattern on CT and biochemically for its cholesterol and calcium content. On the basis of CT appearance, the stones were classified as noncalcified, partially calcified, or heavily calcified. Mechanical fragmentation reduced dissolution time by 25-69% (mean +/- SD, 44 +/- 16%) for the noncalcified stones and by 20-42% (mean +/- SD, 30 +/- 8%) for the partially calcified stones. No significant reduction was observed for the heavily calcified stones. The degree of reduction was inversely related to maximal stone density (r = -.72) and was independent of its pattern of calcification. This study shows that mechanical fragmentation is effective in accelerating gallstone chemolysis by methyl tert-butyl ether for noncalcified and partially calcified but not for heavily calcified stones.
Authors:
D S Lu; C S Ho; L C Allen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  155     ISSN:  0361-803X     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-07-18     Completed Date:  1990-07-18     Revised Date:  2008-02-15    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  67-72     Citation Subset:  AIM; IM    
Affiliation:
Department of Radiology, Toronto Hospital, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Calcium / analysis
Cholelithiasis / analysis,  radiography,  therapy*
Cholesterol / analysis
Ethers*
Humans
Lithotripsy*
Methyl Ethers*
Solubility
Solvents*
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
0/Ethers; 0/Methyl Ethers; 0/Solvents; 1634-04-4/methyl tert-butyl ether; 57-88-5/Cholesterol; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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