Document Detail


Gallbladder visualization in 99Tcm-HMPAO autologous white cell scintigraphy.
MedLine Citation:
PMID:  8692493     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The appearance of the gallbladder in images of patients undergoing 99Tcm-hexamethylpropylene amine oxime (99Tcm-HMPAO) autologous white cell scans (AWCSs) was compared before and after the introduction of fasting in the white cell scan protocol in our department. Before February 1995, when fasting was not required as a condition of the test, gallbladders were identified in 10 and 13% of 128 patients at 1 and 3 h, respectively. After February 1995, when fasting was imposed for the duration of the AWCS procedure, gallbladders were identified in 44 and 58% of 139 patients undergoing an AWCS at 1 and 3 h, respectively (P < 0.01). While further studies are required to show that fasting affects the false-positive rate, the results suggest that the degradation products of 99Tcm-HMPAO may be retained in the biliary system longer during fasting. Fasting should therefore be included in the protocol for an AWCS, particularly in the evaluation of inflammatory bowel disease (IBD) when 99Tcm-HMPAO is the cell label used.
Authors:
J B Neilly; H W Gray
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  17     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-08-23     Completed Date:  1996-08-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  243-5     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, Glasgow Royal Infirmary, UK.
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MeSH Terms
Descriptor/Qualifier:
Eating
Fasting
Gallbladder / physiopathology,  radionuclide imaging*
Humans
Inflammatory Bowel Diseases / physiopathology,  radionuclide imaging
Leukocytes
Organotechnetium Compounds / administration & dosage,  diagnostic use*,  pharmacokinetics
Oximes / administration & dosage,  diagnostic use*,  pharmacokinetics
Technetium Tc 99m Exametazime
Time Factors
Chemical
Reg. No./Substance:
0/Organotechnetium Compounds; 0/Oximes; 100504-35-6/Technetium Tc 99m Exametazime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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