Document Detail


Gallbladder mucin as a pronucleating agent for cholesterol monohydrate crystals in bile.
MedLine Citation:
PMID:  2210647     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mucin is a densely glycosylated macromolecule secreted by the gallbladder epithelium as the principal constituent of gallbladder mucus. Hypersecretion of gallbladder mucus occurs in response to a lithogenic diet in experimental animals, and mucus accumulates as a viscous gel within the gallbladder lumen before gallstone formation. In both animals and man, the initial stage of cholesterol gallstone formation, the nucleation of cholesterol monohydrate crystals, occurs within the mucus gel. Inhibition of mucus secretion with aspirin prevents gallstone formation in the cholesterol-fed prairie dog, indicating the importance of mucus in gallstone formation. Mucin contains domains that bind cholesterol and lecithin transported as vesicles in supersaturated bile. Furthermore, mucin accelerates the nucleation of cholesterol crystals in both supersaturated model and native biles. Binding of cholesterol-enriched vesicles to hydrophobic domains on the mucin protein core appears to be critical for the acceleration of cholesterol crystal nucleation by mucin. Further study of the structure and function of gallbladder mucin should help to elucidate the pathogenesis of cholesterol cholelithiasis.
Authors:
B F Smith
Related Documents :
4036847 - Effect of dietary cholesterol on biliary lipids in patients with gallstones and normal ...
9922197 - Cholangiographic demonstration of the cholecystohepatic duct of luschka.
22890407 - High-density lipoprotein impedes glycation of low-density lipoprotein.
7431117 - Effect of dietary unsaturated oils on the biosynthesis of cholesterol, and on biliary a...
8550907 - Brown midrib sorghum silage for midlactation dairy cows.
7007237 - Effect of dietary salt on hemodynamics of established renal hypertension in the rabbit....
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  12     ISSN:  0270-9139     ISO Abbreviation:  Hepatology     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-10-31     Completed Date:  1990-10-31     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  183S-186S; discussion 186S-188S     Citation Subset:  IM    
Affiliation:
Section of Gastroenterology and Hepatology, Boston City Hospital, Massachusetts 02118.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Chemical Phenomena
Chemistry
Cholelithiasis / etiology
Cholesterol / physiology
Crystallization
Gallbladder / metabolism*
Humans
Models, Biological
Mucins / metabolism,  physiology*
Mucus / physiology
Sciuridae
Grant Support
ID/Acronym/Agency:
R01 DK 39017/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Mucins; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Bile sampling, processing and analysis in clinical studies.
Next Document:  Nonmucous glycoproteins as pronucleating agents.