Document Detail

Gallbladder mucin as a pronucleating agent for cholesterol monohydrate crystals in bile.
MedLine Citation:
PMID:  2210647     Owner:  NLM     Status:  MEDLINE    
Mucin is a densely glycosylated macromolecule secreted by the gallbladder epithelium as the principal constituent of gallbladder mucus. Hypersecretion of gallbladder mucus occurs in response to a lithogenic diet in experimental animals, and mucus accumulates as a viscous gel within the gallbladder lumen before gallstone formation. In both animals and man, the initial stage of cholesterol gallstone formation, the nucleation of cholesterol monohydrate crystals, occurs within the mucus gel. Inhibition of mucus secretion with aspirin prevents gallstone formation in the cholesterol-fed prairie dog, indicating the importance of mucus in gallstone formation. Mucin contains domains that bind cholesterol and lecithin transported as vesicles in supersaturated bile. Furthermore, mucin accelerates the nucleation of cholesterol crystals in both supersaturated model and native biles. Binding of cholesterol-enriched vesicles to hydrophobic domains on the mucin protein core appears to be critical for the acceleration of cholesterol crystal nucleation by mucin. Further study of the structure and function of gallbladder mucin should help to elucidate the pathogenesis of cholesterol cholelithiasis.
B F Smith
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  12     ISSN:  0270-9139     ISO Abbreviation:  Hepatology     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-10-31     Completed Date:  1990-10-31     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  183S-186S; discussion 186S-188S     Citation Subset:  IM    
Section of Gastroenterology and Hepatology, Boston City Hospital, Massachusetts 02118.
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MeSH Terms
Chemical Phenomena
Cholelithiasis / etiology
Cholesterol / physiology
Gallbladder / metabolism*
Models, Biological
Mucins / metabolism,  physiology*
Mucus / physiology
Grant Support
Reg. No./Substance:
0/Mucins; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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