Document Detail

Gallbladder mechanics in newborn piglets.
MedLine Citation:
PMID:  6514445     Owner:  NLM     Status:  MEDLINE    
The mechanical properties of the newborn piglet gallbladder were evaluated in both the stimulated and unstimulated states. The pressure-volume relationships, compliance, and the estimated active tension of the gallbladder were determined in 10 newborn piglets (2-7 days of age). Agonist stimulation was achieved by administration of histamine (25 micrograms/kg/h) and cholecystokinin (CCK) (60 ng/kg/h). Both histamine and CCK increased the intracholecystic pressure at the 50% resting volume from 12.4 cm H2O to 18.9 and 15.5 cm H2O, respectively. This resulted in a significant (p less than 0.05) increase in the active tension. However, no significant changes were observed in the gallbladder compliance after stimulation. These findings characterize the mechanical properties of the normal neonatal gallbladder. The low magnitude of intracholecystic pressure response to agonist stimulation, when compared to adult data, may explain the occurrence of decreased neonatal choledochal bile flow.
G S Kaplan; V K Bhutani; T H Shaffer; N Tran; R J Koslo; M R Wolfson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  18     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1985-01-31     Completed Date:  1985-01-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1181-4     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn / physiology*
Gallbladder / anatomy & histology,  physiology*
Physiology / instrumentation
Swine / physiology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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