Document Detail


Galectins: guardians of eutherian pregnancy at the maternal-fetal interface.
MedLine Citation:
PMID:  22036528     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Galectins are multifunctional regulators of fundamental cellular processes. They are also involved in innate and adaptive immune responses, and play a functional role in immune-endocrine crosstalk. Some galectins have attracted attention in the reproductive sciences because they are highly expressed at the maternal-fetal interface, their functional significance in eutherian pregnancies has been documented, and their dysregulated expression is observed in the 'great obstetrical syndromes'. The evolution of these galectins has been linked to the emergence of eutherian mammals. Based on published evidence, galectins expressed at the maternal-fetal interface may serve as important proteins involved in maternal-fetal interactions, and the study of these galectins may facilitate the prediction, prevention, diagnosis, and treatment of pregnancy complications.
Authors:
Nandor Gabor Than; Roberto Romero; Chong Jai Kim; Michael R McGowen; Zoltan Papp; Derek E Wildman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2011-10-27
Journal Detail:
Title:  Trends in endocrinology and metabolism: TEM     Volume:  23     ISSN:  1879-3061     ISO Abbreviation:  Trends Endocrinol. Metab.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-03     Completed Date:  2012-04-26     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  9001516     Medline TA:  Trends Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  23-31     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Detroit, MI, USA. nthan@med.wayne.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Fetal Proteins / chemistry,  physiology*
Galectins / chemistry,  physiology*
Glycosylation
Humans
Mammals
Maternal-Fetal Exchange
Placentation
Pregnancy / immunology,  physiology*
Pregnancy Maintenance
Pregnancy Proteins / chemistry,  physiology*
Protein Processing, Post-Translational
Grant Support
ID/Acronym/Agency:
ZIA HD002401-17/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Fetal Proteins; 0/Galectins; 0/Pregnancy Proteins
Comments/Corrections

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