Document Detail


Galectin-7 in the control of epidermal homeostasis after injury.
MedLine Citation:
PMID:  18829868     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Galectins, a family of beta-galactoside binding lectins, have recently emerged as novel regulators of tissue homeostasis. Galectin-7 is predominantly expressed in stratified epithelia, especially in epidermis. We report here the generation of galectin-7-deficient mice that are viable and do not display phenotypical abnormalities in skin structure or expression of epidermal markers. However, these mice show unique defects in the maintenance of epidermal homeostasis in response to environmental challenges. First, after UVB irradiation in vivo, the apoptotic response is prematurely triggered and lasts longer in the mutant epidermis. This result contrasts with the proapoptotic role that had been proposed for galectin-7. Second, wound-healing experiments in vivo revealed that galectin-7-deficient mice displayed a reduced reepithelialization potential compared with wild-type littermates. This effect could be attributed to a defect in cell migration. Because galectin-7 is located in the podosomes of keratinocytes migrating out of skin explants in culture, we propose that this glycan-binding protein may directly influence cell/extracellular matrix interactions. Finally, we also detected an unexpected intense hyperproliferative reaction consecutive to both types of stress in galectin-7-deficient mice. Together, these studies provide the first genetic evidence showing that galectin-7 can modulate keratinocyte apoptosis, proliferation, and migration during skin repair.
Authors:
Gaëlle Gendronneau; Sukhvinder S Sidhu; Delphine Delacour; Tien Dang; Chloé Calonne; Denis Houzelstein; Thierry Magnaldo; Françoise Poirier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-01
Journal Detail:
Title:  Molecular biology of the cell     Volume:  19     ISSN:  1939-4586     ISO Abbreviation:  Mol. Biol. Cell     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-01     Completed Date:  2009-03-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9201390     Medline TA:  Mol Biol Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5541-9     Citation Subset:  IM    
Affiliation:
Institut Jacques Monod, Unité Mixte de Recherche Centre National de la Recherche Scientifique 7592, Universités Paris 6 and Paris 7, 75251 Paris Cedex 5, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / physiology
Biological Markers / metabolism
Cortactin / metabolism
Epidermis / cytology,  injuries*,  metabolism*,  radiation effects
Galectins / genetics,  metabolism*
Homeostasis*
Humans
Mice
Mice, Knockout
Ultraviolet Rays
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cortactin; 0/Galectins; 0/Lgals7 protein, mouse
Comments/Corrections

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