| Galectin-3 in cord blood of term and preterm infants. | |
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MedLine Citation:
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PMID: 22236000 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In recent years galectin-3 has gained attention as a signalling molecule, mainly in inflammatory diseases. Data on galectin-3 expression in neonates, however, are limited, and expression of this lectin in cord blood has not yet been reported. The aim of this study was to determine galectin-3 levels in cord blood of term and preterm neonates as well as galectin-3 levels in cord blood of term neonates after stimulation with the prevalent pathogen Streptococcus agalactiae. Cord blood samples were incubated for 24 h and galectin-3 levels were assessed by enzyme-linked immunosorbent assay. There is a positive correlation between gestational age and galectin-3 levels in cord blood. Expression of galectin-3 is significantly higher in cord blood of small-for-gestational-age infants compared to appropriate-for-gestational-age infants. Stimulation with an invasive but not with a colonizing strain of S. agalactiae induced expression of galectin-3. Galectin-3 is expressed constitutively in cord blood of neonates and seems to play a role in the innate immunity of this population. |
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Authors:
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M Demmert; K Faust; M K Bohlmann; B Tröger; W Göpel; E Herting; C Härtel |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 167 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-12 Completed Date: 2012-03-05 Revised Date: 2013-04-08 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
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Languages: eng Pagination: 246-51 Citation Subset: IM |
Copyright Information:
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© 2012 The Authors. Clinical and Experimental Immunology © 2012 British Society for Immunology. |
Affiliation:
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Department of Paediatrics, University of Lübeck, Lübeck, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Birth Weight Blood Cells / immunology, metabolism, microbiology Cells, Cultured / immunology, metabolism, microbiology Ethnic Groups Female Fetal Blood / chemistry*, cytology, immunology Fetal Growth Retardation / blood, immunology Galectin 3 / biosynthesis, blood*, genetics, physiology Germany / epidemiology Gestational Age Humans Immunity, Innate Infant, Newborn / blood*, immunology Infant, Premature / blood*, immunology Infant, Small for Gestational Age / blood*, immunology Male Middle East / ethnology Pregnancy Pregnancy Complications / ethnology, immunology Streptococcus agalactiae / immunology, pathogenicity Turkey / ethnology |
| Chemical | |
Reg. No./Substance:
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0/Galectin 3 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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