Document Detail

Galectin-3 in cord blood of term and preterm infants.
MedLine Citation:
PMID:  22236000     Owner:  NLM     Status:  MEDLINE    
In recent years galectin-3 has gained attention as a signalling molecule, mainly in inflammatory diseases. Data on galectin-3 expression in neonates, however, are limited, and expression of this lectin in cord blood has not yet been reported. The aim of this study was to determine galectin-3 levels in cord blood of term and preterm neonates as well as galectin-3 levels in cord blood of term neonates after stimulation with the prevalent pathogen Streptococcus agalactiae. Cord blood samples were incubated for 24 h and galectin-3 levels were assessed by enzyme-linked immunosorbent assay. There is a positive correlation between gestational age and galectin-3 levels in cord blood. Expression of galectin-3 is significantly higher in cord blood of small-for-gestational-age infants compared to appropriate-for-gestational-age infants. Stimulation with an invasive but not with a colonizing strain of S. agalactiae induced expression of galectin-3. Galectin-3 is expressed constitutively in cord blood of neonates and seems to play a role in the innate immunity of this population.
M Demmert; K Faust; M K Bohlmann; B Tröger; W Göpel; E Herting; C Härtel
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  167     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-12     Completed Date:  2012-03-05     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  246-51     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Clinical and Experimental Immunology © 2012 British Society for Immunology.
Department of Paediatrics, University of Lübeck, Lübeck, Germany.
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MeSH Terms
Birth Weight
Blood Cells / immunology,  metabolism,  microbiology
Cells, Cultured / immunology,  metabolism,  microbiology
Ethnic Groups
Fetal Blood / chemistry*,  cytology,  immunology
Fetal Growth Retardation / blood,  immunology
Galectin 3 / biosynthesis,  blood*,  genetics,  physiology
Germany / epidemiology
Gestational Age
Immunity, Innate
Infant, Newborn / blood*,  immunology
Infant, Premature / blood*,  immunology
Infant, Small for Gestational Age / blood*,  immunology
Middle East / ethnology
Pregnancy Complications / ethnology,  immunology
Streptococcus agalactiae / immunology,  pathogenicity
Turkey / ethnology
Reg. No./Substance:
0/Galectin 3

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