Document Detail


Galectin-3 in cardiac remodeling and heart failure.
MedLine Citation:
PMID:  20425490     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Galectin-3 is a member of the galectin family, which consists of animal lectins that bind beta-galactosides. Recently, a role for galectin-3 in the pathophysiology of heart failure has been suggested. It was observed that galectin-3 is specifically upregulated in decompensated heart failure compared with compensated heart failure in animal models of heart failure. This has been associated with activation of fibroblasts and macrophages, which are a hallmark of cardiac remodeling. Therefore, galectin-3 may be a culprit biomarker in heart failure. Initial clinical observations indicate that galectin-3 may be a useful biomarker for decompensated heart failure, with incremental value over well-used "pressure-dependent" biomarkers, such as B-type natriuretic peptide. Future studies should focus on galectin-3 biology to better address the usefulness of galectin-3 as a biomarker and probe the usefulness of anti-galectin-3 therapy in treating heart failure.
Authors:
Rudolf A de Boer; Lili Yu; Dirk J van Veldhuisen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current heart failure reports     Volume:  7     ISSN:  1546-9549     ISO Abbreviation:  Curr Heart Fail Rep     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-04-28     Completed Date:  2010-09-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101196487     Medline TA:  Curr Heart Fail Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Division of Experimental Cardiology, University Medical Center Groningen, PO Box 30.001, Groningen, 9700 RB, The Netherlands. r.a.de.boer@thorax.umcg.nl
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers
Galectin 3 / blood*,  genetics
Gene Expression
Heart Failure / blood*,  physiopathology*
Humans
Ventricular Remodeling
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Galectin 3
Comments/Corrections
Erratum In:
Curr Heart Fail Rep. 2012 Sep;9(3):163

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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