Document Detail

Galectin-3 expression in pouchitis in patients with ulcerative colitis who underwent ileal pouch-anal anastomosis (IPAA).
MedLine Citation:
PMID:  19278794     Owner:  NLM     Status:  MEDLINE    
Galectin-3, an endogenous pleiotropic beta-galactoside-binding protein, which is expressed by various malignant and normal cells, regulates many biological and pathological processes, including inflammation. In the present study, we tested a possible correlation between the severity of pouchitis in patients with ulcerative colitis who underwent ileal pouch-anal anastomosis (IPAA) and the presence of galectin-3(+) macrophages in pouch mucosa. Paraffin-embedded pouch biopsies from patients with normal pouch function or chronic and recurrent acute pouchitis were immunohistostained with galectin-3, CD68, and smooth muscle actin (SMA) antibodies. Microscopic examination was performed in a blinded fashion. There was a significant decrease in the staining index of galectin-3 in the subepithelial macrophages in patients with chronic pouchitis (0.53, P=0.001; n=12) or recurrent acute pouchitis (0.43, P=0.008; n=10) when compared to patients with no clinical manifestations of pouchitis (0.63, n=12). No significant differences were noted in the lamina propria of small intestine biopsies from the same patients (from 0.63 to 0.68, P=0.24). Galectin-3 staining was restricted to CD68(+) macrophages and not present in myofibroblasts. Clinical manifestation of pouchitis is inversely correlated with galectin-3 expression in the pouches' subepithelial lamina propria macrophages.
Eli Brazowski; Iris Dotan; Hagit Tulchinsky; Irina Filip; Avi Eisenthal
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Publication Detail:
Type:  Journal Article     Date:  2009-03-10
Journal Detail:
Title:  Pathology, research and practice     Volume:  205     ISSN:  1618-0631     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2009  
Date Detail:
Created Date:  2009-07-08     Completed Date:  2009-09-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  551-8     Citation Subset:  IM    
Department of Pathology, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Pathology Institute, Tel Aviv University, Tel Aviv, Israel.
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MeSH Terms
Carrier Proteins / metabolism*
Colitis, Ulcerative / metabolism*,  pathology,  surgery
Colonic Pouches*
Glycoproteins / metabolism*
Macrophages / metabolism,  pathology
Middle Aged
Postoperative Complications / metabolism*,  pathology
Pouchitis / metabolism*,  pathology
Proctocolectomy, Restorative*
Prospective Studies
Young Adult
Reg. No./Substance:
0/Carrier Proteins; 0/Glycoproteins; 0/LGALS3BP protein, human

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