| Galectin-3, cardiac structure and function, and long-term mortality in patients with acutely decompensated heart failure. | |
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MedLine Citation:
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PMID: 20525986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To determine the relationship between galectin-3 concentrations and cardiac structure in patients with acute dyspnoea, and to evaluate the impact of galectin-3 independent of echocardiographic measurements on long-term mortality. METHODS AND RESULTS: One hundred and fifteen patients presenting to the emergency department with acute dyspnoea who had galectin-3 levels and detailed echocardiographic studies on admission were studied. Galectin-3 levels were associated with older age (r = 0.26, P = 0.006), lower creatinine clearance (r = -0.42, P < 0.001), and higher levels of N-terminal-proBNP (r = 0.39, P < 0.001). Higher galectin-3 levels were associated with tissue Doppler E/E(a) ratio (r = 0.35, P = 0.01), a lower right ventricular (RV) fractional area change (r = -0.19, P = 0.05), higher RV systolic pressure (r = 0.37, P < 0.001), and more severe mitral (r = 0.30, P = 0.001) or tricuspid regurgitation (r = 0.26, P = 0.005). In patients diagnosed with heart failure (HF), the association between galectin-3 and valvular regurgitation and RV systolic pressure persisted. In a multivariate Cox regression model, galectin-3 remained a significant predictor of 4-year mortality independent of echocardiographic markers of risk. Dyspnoeic patients with HF and galectin-3 levels above the median value had a 63% mortality; patients less than the median value had a 37% mortality (P = 0.003). CONCLUSION: Among dyspnoeic patients with and without ADHF, galectin-3 concentrations are associated with echocardiographic markers of ventricular function. In patients with ADHF, a single admission galectin-3 level predicts mortality to 4 years, independent of echocardiographic markers of disease severity. |
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Authors:
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Ravi V Shah; Annabel A Chen-Tournoux; Michael H Picard; Roland R J van Kimmenade; James L Januzzi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-05 |
Journal Detail:
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Title: European journal of heart failure Volume: 12 ISSN: 1879-0844 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-02 Completed Date: 2011-06-21 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 826-32 Citation Subset: IM |
Affiliation:
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Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 32 Fruit Street, Yawkey 5984, Boston, MA 02114, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Age Factors Aged Biological Markers Creatinine / metabolism, urine Dyspnea / mortality, physiopathology*, ultrasonography Echocardiography, Doppler Female Galectin 3 / analysis* Heart Failure, Systolic / mortality, physiopathology*, ultrasonography Heart Ventricles / pathology, ultrasonography Humans Male Mitral Valve Insufficiency Multivariate Analysis Natriuretic Peptide, Brain / analysis Peptide Fragments / analysis Prognosis Proportional Hazards Models Risk Factors Statistics, Nonparametric Systole Time Factors United States / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Galectin 3; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain; 60-27-5/Creatinine |
| Comments/Corrections | |
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