| Galectin-1 influences trophoblast immune evasion and emerges as a predictive factor for the outcome of pregnancy. | |
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MedLine Citation:
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PMID: 23002109 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Galectin-1 (gal-1) is expressed at the feto-maternal interface and plays a role in regulating the maternal immune response against placental alloantigens, contributing to pregnancy maintenance. Both decidua and placenta contribute to gal-1 expression and may be important for the maternal immune regulation. Expression of gal-1 within the placenta is considered relevant for cell-adhesion and invasion of trophoblasts, but the role of gal-1 in the immune evasion machinery exhibited by trophoblast cells remains to be elucidated. Here, we analysed gal-1 expression on preimplantation human embryos and first trimester decidua-placenta specimens and serum gal-1 levels to investigate the physiological role played by this lectin during pregnancy. The effect on HLA-G expression in response to stimulation or silencing of gal-1 was also determined in the HIPEC65 human extravillous cytotrophoblast cell line. Compared to normal pregnant women, circulating gal-1 levels were significantly decreased in patients who subsequently suffered a miscarriage. Human embryos undergoing preimplantation development expressed gal-1 on the trophectoderm and inner cell mass. Furthermore, our in vitro experiments showed that exogenous gal-1 positively regulated the membrane-bound HLA-G isoforms (HLA-G1 and G2) in HIPEC65 cells, whereas endogenous gal-1 also induced expression of the soluble isoforms (HLA-G5 and -G6). Our results suggest that gal-1 plays a key role on pregnancy maternal immune regulation by modulating HLA-G expression on trophoblast cells. Circulating gal-1 levels could serve as a predictive factor for pregnancy success in early human gestation. |
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Authors:
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Irene Tirado-González; Nancy Freitag; Gabriela Barrientos; Valerie Shaikly; Olga Nagaeva; Magnus Strand; Lennart Kjellberg; Burghard F Klapp; Lucia Mincheva-Nilsson; Marie Cohen; Sandra M Blois |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-21 |
Journal Detail:
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Title: Molecular human reproduction Volume: - ISSN: 1460-2407 ISO Abbreviation: Mol. Hum. Reprod. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9513710 Medline TA: Mol Hum Reprod Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Charité Center 12 Internal Medicine and Dermatology, Reproductive Medicine Research Group, Medicine University Berlin, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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