| Galectin-1 induces astrocyte differentiation, which leads to production of brain-derived neurotrophic factor. | |
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MedLine Citation:
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PMID: 14693917 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Brain-derived neurotrophic factor (BDNF) is a neuroprotective polypeptide that is thought to be responsible for neuron proliferation, differentiation, and survival. An agent that enhances production of BDNF is expected to be useful for the treatment of neurodegenerative diseases. Here we report that galectin-1, a member of the family of beta-galactoside binding proteins, induces astrocyte differentiation and strongly inhibits astrocyte proliferation, and then the differentiated astrocytes greatly enhance their production of BDNF. Induction of astrocyte differentiation and BDNF production by an endogenous mammalian lectin may be a new mechanism for preventing neuronal loss after injury. |
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Authors:
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Tasuku Sasaki; Jun Hirabayashi; Hiroshi Manya; Ken-ichi Kasai; Tamao Endo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2003-12-23 |
Journal Detail:
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Title: Glycobiology Volume: 14 ISSN: 0959-6658 ISO Abbreviation: Glycobiology Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-04-08 Completed Date: 2004-12-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9104124 Medline TA: Glycobiology Country: England |
Other Details:
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Languages: eng Pagination: 357-63 Citation Subset: IM |
Affiliation:
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Glycobiology Research Group, Tokyo Metropolitan Institute of Gerontology, Foundation for Research on Aging and Promotion of Human Welfare, 35-2 Sakaecho, Itabashi-ku, Tokyo 173-0015, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Asialoglycoproteins / metabolism Astrocytes / cytology*, drug effects*, metabolism Brain Chemistry / drug effects Brain-Derived Neurotrophic Factor / biosynthesis*, immunology, metabolism Cell Differentiation / drug effects* Cell Proliferation / drug effects Cell Shape / drug effects Cells, Cultured Electrophoresis, Polyacrylamide Gel Female Galectin 1 / pharmacology* Humans Immunoblotting Phosphorylation Phosphotyrosine / immunology, metabolism Rats Rats, Inbred F344 Signal Transduction / drug effects alpha-Fetoproteins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Asialoglycoproteins; 0/Brain-Derived Neurotrophic Factor; 0/Galectin 1; 0/alpha-Fetoproteins; 0/asialofetuin; 21820-51-9/Phosphotyrosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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