Document Detail

Galanin inhibits gastric acid secretion through a somatostatin-independent mechanism in mice.
MedLine Citation:
PMID:  15350696     Owner:  NLM     Status:  MEDLINE    
The role of somatostatin in galanin-induced inhibition of gastric acid secretion in urethane-anesthetized mice was investigated by using immunoneutralization of endogenous somatostatin and somatostatin receptor type 2 (SSTR2) knockout mice. Intravenous galanin (10 and 20 microg/kg/h) inhibited pentagastrin-stimulated gastric acid secretion by 47 and 33%, respectively. Somatostatin antibody injected i.v. increased acid secretion by 3.5-fold over basal levels but did not modify the antisecretory effects of galanin. Urethane-anesthetized SSTR2 knockout mice had a basal secretion 14-fold higher than wild-type animals, that was inhibited by galanin (10 and 20 microg/kg/h) by 49 and 31% respectively. In mice galanin inhibits gastric acid secretion through a somatostatin-independent mechanism.
Laura Piqueras; Yvette Taché; Vicente Martinez
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  25     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-09-07     Completed Date:  2005-02-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1287-95     Citation Subset:  IM    
Department of Physiology, Pharmacology and Toxicology, Cardenal Herrera CEU University, Valencia, Spain.
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MeSH Terms
Antibodies, Monoclonal / isolation & purification,  pharmacology*
Galanin / pharmacology*
Gastric Acid / metabolism,  secretion*
Insulin / pharmacology
Mice, Inbred C57BL
Mice, Knockout
Pentagastrin / antagonists & inhibitors,  pharmacology
Somatostatin / metabolism*,  pharmacology
Time Factors
Grant Support
Reg. No./Substance:
0/Antibodies, Monoclonal; 11061-68-0/Insulin; 51110-01-1/Somatostatin; 5534-95-2/Pentagastrin; 88813-36-9/Galanin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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