| Galanin inhibits gastric acid secretion through a somatostatin-independent mechanism in mice. | |
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MedLine Citation:
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PMID: 15350696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of somatostatin in galanin-induced inhibition of gastric acid secretion in urethane-anesthetized mice was investigated by using immunoneutralization of endogenous somatostatin and somatostatin receptor type 2 (SSTR2) knockout mice. Intravenous galanin (10 and 20 microg/kg/h) inhibited pentagastrin-stimulated gastric acid secretion by 47 and 33%, respectively. Somatostatin antibody injected i.v. increased acid secretion by 3.5-fold over basal levels but did not modify the antisecretory effects of galanin. Urethane-anesthetized SSTR2 knockout mice had a basal secretion 14-fold higher than wild-type animals, that was inhibited by galanin (10 and 20 microg/kg/h) by 49 and 31% respectively. In mice galanin inhibits gastric acid secretion through a somatostatin-independent mechanism. |
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Authors:
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Laura Piqueras; Yvette Taché; Vicente Martinez |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Peptides Volume: 25 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-09-07 Completed Date: 2005-02-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: United States |
Other Details:
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Languages: eng Pagination: 1287-95 Citation Subset: IM |
Affiliation:
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Department of Physiology, Pharmacology and Toxicology, Cardenal Herrera CEU University, Valencia, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Monoclonal / isolation & purification, pharmacology* Galanin / pharmacology* Gastric Acid / metabolism, secretion* Insulin / pharmacology Male Mice Mice, Inbred C57BL Mice, Knockout Pentagastrin / antagonists & inhibitors, pharmacology Somatostatin / metabolism*, pharmacology Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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DK-41301/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 11061-68-0/Insulin; 51110-01-1/Somatostatin; 5534-95-2/Pentagastrin; 88813-36-9/Galanin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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