Document Detail

Galanin immunoreactivity increased in chicken supraoptic neurons after activation of the vasotocin system at oviposition.
MedLine Citation:
PMID:  18304849     Owner:  NLM     Status:  MEDLINE    
The avian arginine vasotocin (AVT) synthesized in the hypothalamic magnocellular neurons and released from the posterior pituitary is known to be involved in the regulation of uterine contractions for oviposition in chickens. However, regulation of AVT synthesis and release within the magnocellular hypothalamus has not been elucidated. Galanin, the oviposition inducing factor in the oviduct of the hen, has been demonstrated to have sexually dimorphic stimulatory action in oxytocin- and vasopressin neurons in the mammalian hypothalamus. In this study, galanin and AVT immunoreactivity was investigated around the time of oviposition in the supraoptic nucleus (SON) to determine if galanin modulates AVT synthesis and/or release. Within SON neurons increased AVT immunoreactivity before oviposition and the decreased AVT immunoreactivity after oviposition implied function-related peptide release. The significantly increased number of galanin neurons co-localizing with AVT immediately after oviposition suggests that galanin is involved in the negative feedback to limit AVT release in the SON. Thus, these data support the idea that AVT in the SON is involved in central regulation of oviposition and that AVT release could be modulated by the neuropeptide galanin.
Sabine Klein; Roland Grossmann
Related Documents :
8390839 - A novel putative g protein-coupled receptor highly expressed in lung and testis.
1644189 - Site-directed mutagenesis of a single residue changes the binding properties of the ser...
17143559 - Galanin enhances corticosterone secretion from dispersed rat adrenocortical cells throu...
8082799 - Molecular cloning of a novel candidate g protein-coupled receptor from rat brain.
8898719 - Cloning of a cdna encoding a novel interleukin-1 receptor related protein (il 1r-rp2).
8661159 - Identification of human ogr1, a novel g protein-coupled receptor that maps to chromosom...
17056029 - Felbamate is a subunit selective modulator of recombinant gamma-aminobutyric acid type ...
23792349 - Ligand/kappa-opioid receptor interactions: insights from the x-ray crystal structure.
15951809 - Dynamic mobility of functional gabaa receptors at inhibitory synapses.
Publication Detail:
Type:  Journal Article     Date:  2008-02-05
Journal Detail:
Title:  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology     Volume:  149     ISSN:  1531-4332     ISO Abbreviation:  Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-18     Completed Date:  2008-07-30     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9806096     Medline TA:  Comp Biochem Physiol A Mol Integr Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  411-9     Citation Subset:  IM    
Department of Functional Genomics and Bioregulation, Institute for Farm Animal Genetics, Federal Institute for Animal Health (FLI), 31535 Neustadt, Höltystr. 10, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Chickens / physiology*
Feedback, Physiological
Galanin* / analysis
Immunoenzyme Techniques
Neurons / metabolism,  secretion
Oviposition / physiology*
Supraoptic Nucleus / metabolism*,  secretion*
Vasotocin / analysis,  secretion*
Reg. No./Substance:
88813-36-9/Galanin; 9034-50-8/Vasotocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Massage or music for pain relief in labour: a pilot randomised placebo controlled trial.
Next Document:  Dietary conjugated linoleic acid increases PPAR gamma gene expression in adipose tissue of obese rat...