Document Detail


Galanin immunoreactivity increased in chicken supraoptic neurons after activation of the vasotocin system at oviposition.
MedLine Citation:
PMID:  18304849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The avian arginine vasotocin (AVT) synthesized in the hypothalamic magnocellular neurons and released from the posterior pituitary is known to be involved in the regulation of uterine contractions for oviposition in chickens. However, regulation of AVT synthesis and release within the magnocellular hypothalamus has not been elucidated. Galanin, the oviposition inducing factor in the oviduct of the hen, has been demonstrated to have sexually dimorphic stimulatory action in oxytocin- and vasopressin neurons in the mammalian hypothalamus. In this study, galanin and AVT immunoreactivity was investigated around the time of oviposition in the supraoptic nucleus (SON) to determine if galanin modulates AVT synthesis and/or release. Within SON neurons increased AVT immunoreactivity before oviposition and the decreased AVT immunoreactivity after oviposition implied function-related peptide release. The significantly increased number of galanin neurons co-localizing with AVT immediately after oviposition suggests that galanin is involved in the negative feedback to limit AVT release in the SON. Thus, these data support the idea that AVT in the SON is involved in central regulation of oviposition and that AVT release could be modulated by the neuropeptide galanin.
Authors:
Sabine Klein; Roland Grossmann
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Publication Detail:
Type:  Journal Article     Date:  2008-02-05
Journal Detail:
Title:  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology     Volume:  149     ISSN:  1531-4332     ISO Abbreviation:  Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-18     Completed Date:  2008-07-30     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9806096     Medline TA:  Comp Biochem Physiol A Mol Integr Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  411-9     Citation Subset:  IM    
Affiliation:
Department of Functional Genomics and Bioregulation, Institute for Farm Animal Genetics, Federal Institute for Animal Health (FLI), 31535 Neustadt, Höltystr. 10, Germany. sabine.klein@fli.bund.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Chickens / physiology*
Feedback, Physiological
Female
Galanin* / analysis
Immunoenzyme Techniques
Neurons / metabolism,  secretion
Oviposition / physiology*
Supraoptic Nucleus / metabolism*,  secretion*
Vasotocin / analysis,  secretion*
Chemical
Reg. No./Substance:
88813-36-9/Galanin; 9034-50-8/Vasotocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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