Document Detail

Galanin of the homologous species inhibits insulin secretion in the rat and in the pig.
MedLine Citation:
PMID:  1701068     Owner:  NLM     Status:  MEDLINE    
It is known that pig galanin inhibits insulin secretion in dogs, rats and mice. The present study examined whether species-specific, homologous, galanin inhibits insulin secretion. Thus, the effects of rat galanin were examined in the rat, and the effects of pig galanin were examined in the pig, both in vivo and in vitro. In conscious rats, synthetic rat galanin (2 nmol kg-1) abolished the glucose- (0.56 mmol kg-1) induced increase in plasma insulin levels. In vitro, rat galanin (10(-9) to 10(-6) mol l-1) inhibited glucose- (8.3 mmol l-1) stimulated insulin release from isolated rat islets. In anaesthetized pigs, 15 min infusion of synthetic pig galanin (207 pmol min-1) into the pancreatic artery decreased the insulin output with a subsequent recovery. In vitro, pig galanin (10(-6) mol l-1) inhibited glucose- (8.3 mmol l-1) stimulated insulin release from isolated pig islets. We conclude that homologous galanin inhibits insulin secretion in both the rat and the pig.
S Lindskog; B E Dunning; H Mårtensson; A Ar'Rajab; G J Taborsky; B Ahrén
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  139     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1991-01-04     Completed Date:  1991-01-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  591-6     Citation Subset:  IM    
Department of Pharmacology, University of Lund, Sweden.
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MeSH Terms
Glucose / pharmacology
Insulin / secretion*
Islets of Langerhans / drug effects,  secretion*
Neuropeptides / physiology*
Peptides / physiology*
Rats, Inbred Strains
Species Specificity
Grant Support
Reg. No./Substance:
0/Neuropeptides; 0/Peptides; 11061-68-0/Insulin; 50-99-7/Glucose; 88813-36-9/Galanin

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