| Galactolipids in the formation and function of the myelin sheath. | |
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MedLine Citation:
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PMID: 9672425 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Among the most abundant components of myelin are the galactolipids galactocerebroside (GalC) and sulfatide. In spite of this abundance, the roles that these molecules play in the myelin sheath are not well understood. Until recently, our concept of GalC and sulfatide functions had been principally defined by immunological and chemical perturbation studies that implicate these lipids in oligodendrocyte differentiation, myelin formation, and myelin stability. Recently, however, genetic studies have allowed us to re-analyze the functions of these lipids. Two laboratories have independently generated mice that are incapable of synthesizing either GalC or sulfatide by inactivating the gene encoding the enzyme UDP-galactose:ceramide galactosyltransferase (CGT), which is required for myelin galactolipid synthesis. These galactolipid-deficient animals exhibit a severe tremor, hindlimb paralysis, and display electrophysiological deficits in both the central and peripheral nervous systems. In addition, ultrastructural studies have revealed hypomyelinated white matter tracts with unstable myelin sheaths and a variety of myelin abnormalities including altered node length, reversed lateral loops, and compromised axo-oligodendrocytic junctions. Collectively, these observations indicate that cell-cell interactions, which are essential in the formation and maintenance of a properly functioning myelin sheath, are compromised in these galactolipid-deficient mice. |
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Authors:
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J L Dupree; K Suzuki; B Popko |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Microscopy research and technique Volume: 41 ISSN: 1059-910X ISO Abbreviation: Microsc. Res. Tech. Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-09-17 Completed Date: 1998-09-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9203012 Medline TA: Microsc Res Tech Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 431-40 Citation Subset: IM |
Affiliation:
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UNC Neuroscience Center, University of North Carolina at Chapel Hill, 27599-7250, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Axons / ultrastructure Cell Differentiation Galactolipids Galactosylceramides / physiology Glycolipids / physiology* Mice Mice, Knockout Microscopy, Electron Myelin Sheath / physiology*, ultrastructure Oligodendroglia / cytology Sulfoglycosphingolipids / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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NS01637/NS/NINDS NIH HHS; NS27336/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Galactolipids; 0/Galactosylceramides; 0/Glycolipids; 0/Sulfoglycosphingolipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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