| Galacto-oligosaccharides are bifidogenic and safe at weaning: a double-blind randomized multicenter study. | |
| | |
MedLine Citation:
|
PMID: 19172129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: The primary objective of this study was to determine the bifidogenic effect of galacto-oligosaccharides (GOS) in a follow-on formula and the effects on other intestinal bacteria. Secondary objectives were the effects on stool characteristics, growth, and general well-being. PARTICIPANTS AND METHODS: In a multicenter, double-blind study, 159 healthy infants, formula-fed at enrollment (at 4-6 months), were randomized to an experimental follow-on formula supplemented with 5 g/L (GOS) (77 infants), or to a standard follow-on formula (control, 82 infants). Infants were evaluated at enrollment (study day 1 = sd1), after 6 weeks (study day 2 = sd2), and after an additional 12 weeks (study day 3 = sd3). At each study day, a fresh stool sample for the bacterial counts was collected, and the growth parameters were measured. At sd2, urinary specimens were collected for the evaluation of urinary osmolarity. RESULTS: At sd2 and sd3, the GOS group had a higher median number (colony-forming units per gram of stool) of bifidobacteria than did the control group (sd2 GOS 9.2 x 10(9) vs control 4.4 x 10(9), P = 0.012); (sd3 GOS 7.2 x 10(9) vs control 2.4 x 10(9), P = 0.027). Other bacteria did not show any significant differences between the 2 groups at all study days. The GOS produced softer stools but had no effect on stool frequency. The urinary osmolarity (mOsm/L) at sd2 was comparable in both groups. Supplementation had no influence on the incidence of gastrointestinal side effects or on the growth of the infants. CONCLUSIONS: These data indicate that the addition of GOS (5 g/L) to a follow-on formula positively influences the bifidobacteria flora and the stool consistency in infants during the supplementation period at weaning. No local or systemic side effects were recorded. |
| | |
Authors:
|
Silvia Fanaro; Berit Marten; Rossana Bagna; Vittorio Vigi; Claudio Fabris; Luis Peña-Quintana; Federico Argüelles; Katharina E Scholz-Ahrens; Günther Sawatzki; Richard Zelenka; Jürgen Schrezenmeir; Michael de Vrese; Enrico Bertino |
Related Documents
:
|
8350219 - Zinc supplementation in very-low-birth-weight infants. 15237239 - Coq10 plasmatic levels in breast-fed infants compared to formula-fed infants. 1258629 - Influence of fat and carbohydrate content of diet on food intake and growth of male inf... 7762449 - Faecal flora in the newborn. effect of lactoferrin and related nutrients. 12663289 - Infants discriminate between natural and synthetic vitamin e. 19962799 - Breastfeeding facilitates acceptance of a novel dietary flavour compound. 20479779 - Neurobiology of injury to the developing brain. 6768869 - Ventilatory response to carbon dioxide of infants following chronic prenatal methadone ... 15982119 - Lost in the wilderness: terror management, action orientation, and nature evaluation. |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of pediatric gastroenterology and nutrition Volume: 48 ISSN: 1536-4801 ISO Abbreviation: J. Pediatr. Gastroenterol. Nutr. Publication Date: 2009 Jan |
Date Detail:
|
Created Date: 2009-01-27 Completed Date: 2009-04-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8211545 Medline TA: J Pediatr Gastroenterol Nutr Country: United States |
Other Details:
|
Languages: eng Pagination: 82-8 Citation Subset: IM |
Affiliation:
|
Neonatal Intensive Care Unit, University of Ferrara, Ferrara, Italy. fnrslv@unife.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bifidobacterium
/
drug effects,
growth & development* Colony Count, Microbial Double-Blind Method Feces / microbiology Female Galactose / administration & dosage*, adverse effects Humans Infant Infant Formula / administration & dosage* Intestines / microbiology Male Oligosaccharides / administration & dosage*, adverse effects Osmolar Concentration Placebos Urine Weaning |
| Chemical | |
Reg. No./Substance:
|
0/Oligosaccharides; 0/Placebos; 26566-61-0/Galactose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: British paediatric surveillance unit study of biliary atresia: outcome at 13 years.
Next Document: Zinc therapy for diarrhoea improves growth among Bangladeshi infants 6 to 11 months of age.