Document Detail

Gait analysis may help to distinguish hereditary spastic paraplegia from cerebral palsy.
MedLine Citation:
PMID:  21330136     Owner:  NLM     Status:  Publisher    
Hereditary spastic paraplegia (HSP) designates a group of genetic disorders typically leading to spasticity in the lower limbs and consequently to gait disorders. Although the symptoms are similar to those of cerebral palsy (CP), the correct diagnosis is important for treatment recommendations as one condition is progressive in nature whereas the other is not. Due to the heterogeneity of HSP, genetic testing is complex and in some genetic forms still not possible. The aim of this study was, therefore, to investigate if instrumented 3D-gait analysis could help distinguish between these two conditions. The gait pattern of 29 patients with HSP was compared with that of 29 patients with CP who were matched in age, sex, and the extent of gait disturbance and also to 29 typically developing subjects for reference. More than 3000 gait parameters were evaluated for their relevance to classify patients into diagnostic groups. Cluster analysis revealed that these gait features may classify only subgroups of symptoms as the gait pattern is very heterogeneous within each diagnosis group. However, prolonged hip extension, knee extension, and ankle plantar flexion were identified as indicators for HSP. In addition, large trunk tilt velocities appear unique in some cases of HSP. These indicators in gait pattern may contribute in establishing the diagnosis of HSP, which is important in predicting outcome when planning surgical treatment for functional improvements in these patients.
Sebastian I Wolf; Frank Braatz; Dimitrios Metaxiotis; Petra Armbrust; Thomas Dreher; Leonhard Döderlein; Ralf Mikut
Related Documents :
8485026 - The pharmacokinetics of intravenous ondansetron in patients with hepatic impairment.
21253296 - A matched case-control study using the propensity score on differences in the character...
21319346 - Utility of procalcitonin as an early diagnostic marker of bacteremia in patients with a...
21431086 - Longitudinal mri volumetric evaluation in patients with familial mesial temporal lobe e...
3698626 - Efficacy of abdominal computed tomography in evaluation of possible abdominal abscess.
1736176 - A noninvasive protocol for anterior temporal lobectomy.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-15
Journal Detail:
Title:  Gait & posture     Volume:  -     ISSN:  1879-2219     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9416830     Medline TA:  Gait Posture     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Department of Orthopaedic Surgery, University of Heidelberg, Schlierbacher Landstr. 200a, 69118 Heidelberg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Mind your step: Metabolic energy cost while walking an enforced gait pattern.
Next Document:  Opposing oncogenic activities of small DNA tumor virus transforming proteins.