| Gains in bone mineral density with resolution of vitamin D intoxication. | |
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MedLine Citation:
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PMID: 9245225 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Vitamin D intoxication is associated with the mobilization of skeletal calcium. OBJECTIVE: To ascertain how the resolution of vitamin D intoxication affects bone density. DESIGN: Case series. SETTING: Referral service for metabolic bone disease in a tertiary care teaching hospital. PATIENTS: Four patients with osteoporosis who were each using several nonprescription dietary supplements and were found to have fasting hypercalciuria. INTERVENTION: Discontinuation of use of dietary supplements. MEASUREMENTS: Serial measurement of serum levels of 25-hydroxyvitamin D, ratio of fasting urinary calcium to creatinine, and bone mineral density for 3 years. RESULTS: Discontinuation of use of dietary supplements resulted in the normalization of serum levels of 25-hydroxyvitamin D, the normalization of the ratio of urinary calcium to creatinine, and a mean annual increase in bone mineral density (+/- SD) of 1.9% +/- 0.5%. CONCLUSIONS: Occult vitamin D intoxication was detected in patients who were using dietary supplements that contained an unadvertised high level of vitamin D. Resolution of vitamin D intoxication was associated with a rebound in bone mineral density. |
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Authors:
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J S Adams; G Lee |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Annals of internal medicine Volume: 127 ISSN: 0003-4819 ISO Abbreviation: Ann. Intern. Med. Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-08-05 Completed Date: 1997-08-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372351 Medline TA: Ann Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 203-6 Citation Subset: AIM; IM |
Affiliation:
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Cedars-Sinal Medical Center, Los Angeles, California, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bone Density / drug effects* Calcium / urine Creatinine / urine Female Food, Fortified / poisoning* Humans Male Middle Aged Osteoporosis / chemically induced*, metabolism Vitamin D / analogs & derivatives, blood, poisoning* |
| Grant Support | |
ID/Acronym/Agency:
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RR00425-28/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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1406-16-2/Vitamin D; 60-27-5/Creatinine; 64719-49-9/25-hydroxyvitamin D; 7440-70-2/Calcium |
| Comments/Corrections | |
Comment In:
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Ann Intern Med. 1998 Mar 15;128(6):507; author reply 508
[PMID:
9499343
]
Ann Intern Med. 1998 Mar 15;128(6):507-8 [PMID: 9499344 ] Ann Intern Med. 1997 Aug 1;127(3):231-3 [PMID: 9245230 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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