Document Detail

Gain control in CA1 pyramidal cells using changes in somatic conductance.
MedLine Citation:
PMID:  20053905     Owner:  NLM     Status:  MEDLINE    
Gain modulation is an important feature of neural activity. Previous work has focused on the ability of background synaptic noise to modulate the slope (i.e., gain) of the frequency-current (f-I) relationship in neurons. To date, demonstrations of gain control that are independent of synaptic noise have been limited. We investigated the effects of increasing somatic conductance in the form of tonic inhibition on the initial and steady-state f-I relationship of CA1 pyramidal cells. We find that increasing membrane conductance reduces the gain of the steady-state f-I relationship through a graded increase in the magnitude of spike frequency adaptation. Increased adaptation arises through a conductance-induced depolarization of spike voltage threshold. Thus, by increasing the magnitude of spike frequency adaptation, added conductance can reduce the gain of the steady-state f-I relationship in the absence of random background membrane fluctuations.
Fernando R Fernandez; John A White
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  30     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-07     Completed Date:  2010-02-04     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  230-41     Citation Subset:  IM    
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MeSH Terms
Action Potentials / physiology*
CA1 Region, Hippocampal / physiology*
Electric Conductivity*
Membrane Potentials / physiology
Pyramidal Cells / physiology*
Rats, Long-Evans
Grant Support
R01 MH085074/MH/NIMH NIH HHS; R13 MH077346/MH/NIMH NIH HHS; R13 MH077346-01/MH/NIMH NIH HHS; //Canadian Institutes of Health Research

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