Document Detail


Gain of chromosome arm 17q and adverse outcome in patients with neuroblastoma.
MedLine Citation:
PMID:  10379019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Gain of genetic material from chromosome arm 17q (gain of segment 17q21-qter) is the most frequent cytogenetic abnormality of neuroblastoma cells. This gain has been associated with advanced disease, patients who are > or =1 year old, deletion of chromosome arm 1p, and amplification of the N-myc oncogene, all of which predict an adverse outcome. We investigated these associations and evaluated the prognostic importance of the status of chromosome 17. METHODS: We compiled molecular cytogenetic analyses of chromosome 17 in primary neuroblastomas in 313 patients at six European centers. Clinical and survival information were collected, along with data on 1p, N-myc, and ploidy. RESULTS: Unbalanced gain of segment 17q21-qter was found in 53.7 percent of the tumors, whereas the chromosome was normal in 46.3 percent. The gain of 17q was characteristic of advanced tumors and of tumors in children > or =1 year of age and was strongly associated with the deletion of 1p and amplification of N-myc. No tumor showed amplification of N-myc in the absence of either deletion of 1p or gain of 17q. Gain of 17q was a significant predictive factor for adverse outcome in univariate analysis. Among the patients with this abnormality, overall survival at five years was 30.6 percent (95 percent confidence interval, 21 to 40 percent), as compared with 86.0 percent (95 percent confidence interval, 78 to 91 percent) among those with normal 17q status. in multivariate analysis, gain of 17q was the most powerful prognostic factor, followed by the presence of stage 4 disease and deletion of 1p (hazard ratios, 3.4, 2.3, and 1.9, respectively). CONCLUSIONS: Gain of chromosome segment 17q21-qter is an important prognostic factor in children with neuroblastoma.
Authors:
N Bown; S Cotterill; M Lastowska; S O'Neill; A D Pearson; D Plantaz; M Meddeb; G Danglot; C Brinkschmidt; H Christiansen; G Laureys; F Speleman; J Nicholson; A Bernheim; D R Betts; J Vandesompele; N Van Roy
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The New England journal of medicine     Volume:  340     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-06-24     Completed Date:  1999-06-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1954-61     Citation Subset:  AIM; IM    
Affiliation:
Department of Human Genetics, University of Newcastle upon Tyne, United Kingdom. nicholas.bown@ncl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Child, Preschool
Chromosome Deletion
Chromosomes, Human, Pair 1 / genetics
Chromosomes, Human, Pair 17*
Gene Amplification
Genes, myc / genetics
Humans
Infant
Multivariate Analysis
Neoplasm Staging
Neuroblastoma / genetics*,  mortality,  pathology
Prognosis
Regression Analysis
Risk Factors
Survival Rate
Translocation, Genetic*
Comments/Corrections
Comment In:
N Engl J Med. 1999 Jun 24;340(25):1992-3   [PMID:  10379025 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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