Document Detail

Gain of 1q in pediatric myelodysplastic syndromes.
MedLine Citation:
PMID:  16472857     Owner:  NLM     Status:  MEDLINE    
The presence of acquired clonal cytogenetic abnormalities in hematopoietic cells is one of the diagnostic hallmarks of myelodysplastic syndromes (MDS). Such anomalies may help in defining prognostic groups. We analyzed eight pediatric MDS, and herein describe three new cases, one de novo and two therapy-related, presenting an unbalanced rearrangement of 1q: one of them resulted in a derivative chromosome 6 apparently identical to a previously described one. We also review all the cases of gain of 1q reported in de novo and therapy-related childhood MDS.
Cristina Morerio; Annamaria Rapella; Elisa Tassano; Edoardo Lanino; Concetta Micalizzi; Cristina Rosanda; Claudio Panarello
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-02-10
Journal Detail:
Title:  Leukemia research     Volume:  30     ISSN:  0145-2126     ISO Abbreviation:  Leuk. Res.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-09-05     Completed Date:  2007-10-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1437-41     Citation Subset:  IM    
Dipartimento di Ematologia ed Oncologia Pediatrica, IRCCS Istituto Giannina Gaslini, Largo G. Gaslini 5, 16147 Genova, Italy.
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MeSH Terms
Child, Preschool
Chromosomes, Human, Pair 1 / genetics*
Chromosomes, Human, Pair 6 / genetics
Fatal Outcome
Myelodysplastic Syndromes / diagnosis,  genetics*
Translocation, Genetic / genetics

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