Document Detail


Gadolinium promoted proliferation and enhanced survival in human cervical carcinoma cells.
MedLine Citation:
PMID:  19184457     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of gadolinium chloride (Gd) on the proliferation of HeLa cells was investigated at lower concentration. The results obtained by MTT and cell cycle analysis showed that Gd promoted proliferation by inducing S phase entry in HeLa cells at the concentration less than 100 microM. It was further evidenced by both an increase in the levels of phosphorylation of retinoblastoma protein (pRb) and a remarkable increase in cyclin E expression. Moreover, the survival of cells, exposed to Gd up to 3-5 days, was increased compared with control. The attenuation of the serum deprivation-induced cell loss by Gd was associated with the sustained activation of FAK (PY(397)) and the delayed activation of JNKs pathway. Besides, it appeared that Gd promoted cell proliferation and survival in HeLa cells was not contributed to the ROS generation. Based on the present results, both positive and negative effects of the lanthanides as potential drugs or diagnostic agents are discussed.
Authors:
Ying Zhang; Li-Juan Fu; Jin-Xia Li; Xiao-Gai Yang; Xiao-Da Yang; Kui Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-29
Journal Detail:
Title:  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine     Volume:  22     ISSN:  1572-8773     ISO Abbreviation:  Biometals     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-14     Completed Date:  2009-07-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9208478     Medline TA:  Biometals     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  511-9     Citation Subset:  IM    
Affiliation:
Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University Health Science Center, 100191 Beijing, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Blotting, Western
Cell Cycle / drug effects
Cell Proliferation / drug effects*
Cell Survival / drug effects*
Cyclin E / metabolism
Gadolinium / pharmacology*
Gene Expression / drug effects
Hela Cells
Humans
Phosphorylation / drug effects
Reactive Oxygen Species / metabolism
Retinoblastoma Protein / metabolism
Chemical
Reg. No./Substance:
0/Cyclin E; 0/Reactive Oxygen Species; 0/Retinoblastoma Protein; 10138-52-0/gadolinium chloride; 7440-54-2/Gadolinium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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