Document Detail


Gadolinium loaded nanoparticles in theranostic magnetic resonance imaging.
MedLine Citation:
PMID:  22521487     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Theranostic magnetic resonance imaging (MRI) is now receiving a growing interest in imaging-guided drug delivery, monitoring the treatment and personalized administration etc. Theranostic agents are essential for the usage of theranostic MRI. Among different kinds of theranostic agents, gadolinium loaded nanoparticles (GdNPs) are one of the most promising theranostic agents which are very promising in combination of diagnostics (molecular imaging) and therapeutics (molecular therapy) functions in a single platform. In this review, we provided fully discussion on the design considerations of GdNPs as a platform for theranostic MRI. The mainly factors that affect the preparation process, such as GdNP materials, the loading of Gd/drugs in GdNPs, and the passive and active targeting strategies were discussed. Major classes of GdNPs including lipid-based nanoparticles, polymeric nanoparticles, micelles, dendrimers and Gd-silica nanoparticles were described in detail. The use of GdNPs as theranostic agents offers potential advantages that change the usual cancer therapy from separating diagnosis and treatment to theranostic approach.
Authors:
Yongjun Liu; Na Zhang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-20
Journal Detail:
Title:  Biomaterials     Volume:  -     ISSN:  1878-5905     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Affiliation:
School of Pharmaceutical Science, Shandong University, Ji'nan, People's Republic of China.
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