| Gadolinium-ethoxybenzyl-DTPA, a new liver-directed magnetic resonance contrast agent. Absence of acute hepatotoxic, cardiovascular, or immunogenic effects. | |
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MedLine Citation:
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PMID: 8425849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONALE AND OBJECTIVES: Gadolinium-ethoxybenzyl-DTPA (Gd-EOB-DTPA) is a recently introduced experimental magnetic resonance (MR) contrast agent for hepatic imaging. Although liver enhancement has been investigated in a number of animal models, tolerance evaluations of Gd-EOB-DTPA injection have been limited. METHODS: The authors investigated acute hepatotoxicity in an isolated perfused rat liver model, cardiovascular effects in the anesthetized rat, and potential immunogenicity of Gd-EOB-DTPA using detection of specific antibodies. RESULTS: Using perfused rat liver model, no significant deviation could be observed for functional parameters, liver enzymes, or potassium release, comparing Gd-EOB-DTPA to a control, but there was a significant choleresis (+250% bile flow). Hemodynamic effects of Gd-EOB-DTPA were observed after femoral bolus injection, but only with relatively high dosages (0.3-0.5 mmol/kg, 10-fold the likely clinical dose in humans). Experimental conditions, idealized for antibody induction, failed to cause an IgG immune response to Gd-EOB-DTPA in the intact rat. CONCLUSIONS: The results further support preliminary conclusions that Gd-EOB-DTPA is a well-tolerated MR contrast agent. |
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Authors:
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A M?hler; O Cl?ment; M Saeed; J R Lake; D P Stites; Y Berthez?ne; R C Brasch |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Investigative radiology Volume: 28 ISSN: 0020-9996 ISO Abbreviation: Invest Radiol Publication Date: 1993 Jan |
Date Detail:
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Created Date: 1993-03-01 Completed Date: 1993-03-01 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 26-32 Citation Subset: IM |
Affiliation:
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Contrast Media Laboratory, University of California, San Francisco 94143-0628. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile / drug effects Contrast Media / toxicity* Enzyme-Linked Immunosorbent Assay Female Gadolinium DTPA* Hemodynamics / drug effects* Immunoglobulin G / drug effects* Liver / anatomy & histology, drug effects* Liver Diseases / diagnosis Magnetic Resonance Imaging* Male Organometallic Compounds / toxicity* Pentetic Acid / toxicity* Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
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AM-26743/AM/NIADDK NIH HHS; CA 49786/CA/NCI NIH HHS; HL 07570-08/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Immunoglobulin G; 0/Organometallic Compounds; 0/gadolinium ethoxybenzyl DTPA; 67-43-6/Pentetic Acid; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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