Document Detail


Gadolinium-enhanced MR imaging demonstrates abduction-caused hip ischemia and its reversal in piglets.
MedLine Citation:
PMID:  8610567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To determine if gadolinium-enhanced MR imaging can detect early reversible ischemia of the capital femoral epiphysis and physis induced by hip hyperabduction in piglets.
MATERIALS AND METHODS: Thirteen 1- to 3-week-old piglets were placed in maximal bilateral hip abduction and then studied with dynamic gadolinium-enhanced MR imaging 1-6 hr later to assess ischemia of the 26 femoral heads. The piglets were then allowed to ambulate freely for 1 or 7 days and reimaged in neutral position to assess reperfusion. We evaluated enhancement on MR images and compared them with histologic findings.
RESULTS: Decreased or absent enhancement, interpreted as ischemia, developed after maximal hip abduction in all 26 cartilaginous epiphyses and 85% of the 26 physes. The most frequently seen abnormality was a sharply marginated, nonenhancing area in the anterior part of the femoral head. A smaller area of decreased enhancement developed in the posterior part of the femoral head adjacent to the acetabular rim. The secondary center of ossification was ischemic in 10 (56%) of the 18 hips after 1 hr of abduction and in all 8 hips after 4 or 6 hr (p = .02). The overall severity of ischemia was greater with longer abduction times (p < .001) and greater degrees of abduction (p < .01). Reperfusion was complete in two (17%) of the 12 hips after 1 day of ambulation and in all 10 (100%) after 1 week of ambulation.
CONCLUSION: Enhanced MR imaging detects early ischemia of the epiphyseal and physeal cartilage and the epiphyseal marrow. In piglets, ischemia due to maximal abduction is reversible if corrected within 6 hr.
Authors:
D Jaramillo; O L Villegas-Medina; D K Doty; J R Dwek; B J Ransil; R V Mulkern; F Shapiro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  166     ISSN:  0361-803X     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-05-28     Completed Date:  1996-05-28     Revised Date:  2013-01-14    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  879-87     Citation Subset:  AIM; IM    
Affiliation:
Department of Radiology, Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Contrast Media*
Epiphyses / pathology
Femur Head / blood supply*,  pathology*
Femur Head Necrosis / diagnosis,  etiology
Gadolinium / diagnostic use
Heterocyclic Compounds / diagnostic use*
Hip Dislocation, Congenital / therapy*
Immobilization / adverse effects
Ischemia / diagnosis*,  etiology,  pathology
Magnetic Resonance Imaging*
Organometallic Compounds / diagnostic use*
Swine
Time Factors
Grant Support
ID/Acronym/Agency:
AR42396-02/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Heterocyclic Compounds; 0/Organometallic Compounds; 0199MV609F/gadoteridol; 7440-54-2/Gadolinium

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