| Gadolinium diethylenetriaminepentaacetate enhancement kinetics in the menisci of asymptomatic subjects: a first step towards a dedicated dGEMRIC (delayed gadolinium-enhanced MRI of cartilage)-like protocol for biochemical imaging of the menisci. | |
| | |
MedLine Citation:
|
PMID: 21438048 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
It was our aim to investigate the gadolinium diethylenetriaminepentaacetate (Gd-DTPA(2-) ) enhancement kinetics in the menisci of the knee joint over a prolonged period of time. Six asymptomatic volunteers (four men and two women; mean age, 25 ± 2.4 years) were enrolled. Sagittal, T(1) -weighted, spin-echo MR sequences of the right knee joint were obtained at 3 T. Imaging was performed before (baseline), 1 h after and in half-hour intervals up to 9 h after the intravenous administration of 0.2 mmol/kg of Gd-DTPA(2-) . To measure the rates of contrast enhancement relative to the baseline, regions of interest that covered the anterior and posterior horns of the medial and lateral meniscus were defined on each of two adjacent sections, and enhancement curves were constructed. An enhancement peak between 2.5 and 4.5 h after Gd-DTPA(2-) administration was observed, and analysis of variance also revealed no significant difference (p = 0.94), in terms of enhancement, within this time interval. Pair-wise, post hoc testing also revealed no significant differences between 2.5 and 3, 3 and 3.5, 3.5 and 4, and 4 and 4.5 h post Gd-DTPA(2-) application. Our preliminary data therefore suggest that the time window suitable for a dGEMRIC (delayed gadolinium-enhanced MRI of cartilage)-like T(1) mapping of the menisci is relatively short, and lies between 2.5 and 4.5 h after Gd-DTPA(2-) injection. Copyright © 2011 John Wiley & Sons, Ltd. |
| | |
Authors:
|
Marius E Mayerhoefer; Tallal C Mamisch; Georg Riegler; Goetz H Welsch; Tomas Dobrocky; Michael Weber; Sebastian Apprich; Georg Scheurecker; Pavol Szomolanyi; Stefan Puchner; Siegfried Trattnig |
Related Documents
:
|
9443738 - Preclinical characterization and in vivo imaging studies of an engineered recombinant t... 11355848 - In vitro assembly of novel cholera toxin-like complexes. 12532018 - Role of anthocyanidin reductase, encoded by banyuls in plant flavonoid biosynthesis. 21258138 - Registration of 2d x-ray images to 3d mri by generating pseudo-ct data. 8478458 - Ultrasonography and biliary extracorporeal shock-wave lithotripsy. 16194168 - Local intense mosaic pattern at site of flail mitral leaflet: report of a new color dop... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-24 |
Journal Detail:
|
Title: NMR in biomedicine Volume: - ISSN: 1099-1492 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8915233 Medline TA: NMR Biomed Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 John Wiley & Sons, Ltd. |
Affiliation:
|
Department of Radiology, MR Center, Medical University of Vienna, Vienna, Austria. marius.mayerhoefer@meduniwien.ac.at. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparative Study of Spasmolytic Properties, Antioxidant Activity and Phenolic Content of Arbutus un...
Next Document: Determination of carbohydrates in medicinal plants-comparison between TLC, mf-MELDI-MS and GC-MS.