| Gadofosveset. | |
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MedLine Citation:
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PMID: 16706555 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gadofosveset is the first gadolinium-based magnetic resonance (MR) imaging agent designed to image the blood pool. At clinically relevant concentrations, gadofosveset is highly bound to human serum albumin, which has the effect of increasing its signal-enhancing properties above that of non-protein bound imaging agents, as well as increasing its plasma half-life, allowing for increased imaging times. The use of gadofosveset-enhanced MR angiography was compared with non-enhanced MR angiography in four open-label, multicentre studies in adults with known or suspected arterial disease. Significant improvements in the accuracy and specificity of diagnosis were seen with gadofosveset in patients with aortoiliac disease in two studies. Sensitivity was also improved, with all three readers in one study, and two of three readers in the other study, showing significant improvements with gadofosveset use. Significant improvements in sensitivity, specificity, and accuracy were also seen with gadofosveset in a renal artery disease study. Specificity was significantly improved in patients with pedal artery disease across all readers, with accuracy and sensitivity significantly improved in two of three and one of three readers. Gadofosveset was generally well tolerated in clinical trials, with most adverse events being mild or moderate in severity. |
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Authors:
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Sheridan Henness; Gillian M Keating |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Drugs Volume: 66 ISSN: 0012-6667 ISO Abbreviation: Drugs Publication Date: 2006 |
Date Detail:
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Created Date: 2006-05-18 Completed Date: 2006-08-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600076 Medline TA: Drugs Country: New Zealand |
Other Details:
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Languages: eng Pagination: 851-7 Citation Subset: IM |
Affiliation:
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Adis International Limited, 41 Centorian Drive, Mairangi Bay, Auckland 1311, New Zealand. demail@adis.co.nz |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Contrast Media / administration & dosage, adverse effects Gadolinium Humans Magnetic Resonance Angiography / methods* Molecular Structure Organometallic Compounds / adverse effects, chemistry, diagnostic use* Reproducibility of Results Sensitivity and Specificity Vascular Diseases / diagnosis* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Organometallic Compounds; 0/gadofosveset trisodium; 7440-54-2/Gadolinium |
| Comments/Corrections | |
Comment In:
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Drugs. 2006;66(6):858-9
[PMID:
16706556
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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