| Gadofosveset-enhanced MR imaging for the preoperative evaluation of potential living kidney donors: correlation with intraoperative findings. | |
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MedLine Citation:
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PMID: 20922646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The purpose of this study was to evaluate the blood pool contrast agent gadofosveset for MR angiography (MRA) of the renal vasculature in living kidney donors (LKD). MATERIALS AND METHODS: Of the 28 consecutive potential LKDs (13 men, 15 women; mean age 55.14 years ± 11.97) initially included in this prospective study, 20 patients underwent surgery and were considered for further evaluation. 7 acquisitions of a 3D T 1-weighted FLASH sequence were performed following administration of gadofosveset for the assessment of the vascular anatomy and collecting system at predefined time points at 1.5 T. All MR exams were prospectively analyzed by 2 radiologists in consensus mode prior to surgery. In addition, ROI-based relative SNR measurements were performed in the vena cava inferior and abdominal aorta. RESULTS: MR image acquisition was completed in all 20 potential living donors. In 8 donors an additional CT scan was available for further comparison with the collateral anatomy, resulting in a total of 28 analyzed kidneys. MRA disclosed 36 renal arteries, since 8 accessory arteries were found in 8 subjects. One accessory artery and one case of fibromuscular dysplasia were missed by MRA. The venous anatomy and the collecting system were assessed correctly with MRI. In addition, MRI diagnosed two renal cell carcinomas. The overall sensitivity and positive predictive value of gadofosveset-enhanced MRI on a per kidney basis were 92.9 % and 100 %, respectively. CONCLUSION: Gadofosveset enables accurate evaluation of potential LKDs. |
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Authors:
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J Kuhlemann; D Blondin; D Grotemeyer; P Zgoura; D Reichelt; W Heinen; A Scherer; R S Lanzman |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2010-10-04 |
Journal Detail:
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Title: RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin Volume: 182 ISSN: 1438-9010 ISO Abbreviation: Rofo Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-29 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7507497 Medline TA: Rofo Country: Germany |
Other Details:
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Languages: eng Pagination: 1001-9 Citation Subset: IM |
Copyright Information:
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© Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
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Institut für Radiologie, Uniklinikum Düsseldorf. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aorta, Abdominal / pathology Carcinoma, Renal Cell / diagnosis Contrast Media* Female Fibromuscular Dysplasia / diagnosis Gadolinium / diagnostic use* Hemangioma / diagnosis Humans Image Enhancement* Image Processing, Computer-Assisted / standards* Imaging, Three-Dimensional / standards* Incidental Findings Kidney / blood supply*, pathology* Kidney Neoplasms / diagnosis Kidney Transplantation* Living Donors* Magnetic Resonance Angiography / standards* Male Middle Aged Organometallic Compounds / diagnostic use* Reference Standards Renal Artery / pathology Renal Artery Obstruction / diagnosis Sensitivity and Specificity Statistics as Topic Tomography, Spiral Computed / standards Urography / standards Vena Cava, Inferior / pathology |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Organometallic Compounds; 0/gadofosveset trisodium; 7440-54-2/Gadolinium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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